Toxic effects of mercuric sulfide on immune organs in mice

• Published in: Immunopharmacology and immunotoxicology Vol. 32; no. 2; pp. 277 - 283
• Main Authors: Son, Hee-Young, Lee, Soyoung, Park, Seung-Bin, Kim, Mi-Sun, Choi, Eun-Ju, Singh, Thoudam S.K., Bae, Yunju, Kwack, Seung Jun, Kang, Tae Seok, Shin, Hong-In, Baek, Moon-Chang, Kim, Sang- Hyun
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.06.2010; Taylor & Francis
• Subjects: Administration, Oral; Animals; Chemical and Drug Induced Liver Injury - etiology; Chemical and Drug Induced Liver Injury - immunology; Chemical and Drug Induced Liver Injury - pathology; Cytokines - genetics; Cytokines - immunology; Gastrointestinal Tract - metabolism; Gene Expression - drug effects; Hepatocytes - drug effects; Hepatocytes - pathology; Immune systems; Liver - drug effects; Liver - enzymology; Liver - metabolism; Liver - pathology; Liver Function Tests; Lymphocytes - cytology; Lymphocytes - drug effects; Lymphocytes - immunology; Male; Mercuric sulfide; Mercury Compounds - pharmacokinetics; Mercury Compounds - toxicity; Mice; Mice, Inbred ICR; Organ Size - drug effects; Reverse Transcriptase Polymerase Chain Reaction; Spleen - drug effects; Spleen - immunology; Spleen - pathology; T lymphocytes; Thymus Gland - drug effects; Thymus Gland - immunology; Thymus Gland - pathology; Tissue Distribution

Mercuric sulfide (HgS) is a major component of cinnabar, which has been used as a sedative drug in China for more than 2000 years. Because its toxicological effects are still unclear, we attempted to verify the toxic effects of HgS, focused on liver and immune organs such as the spleen and thymus. M...