Ventromedial prefrontal cortex damage alters relative risk tolerance for prospective gains and losses

• Published in: Neuropsychologia Vol. 79; no. Pt A; pp. 70 - 75
• Main Authors: Pujara, Maia S., Wolf, Richard C., Baskaya, Mustafa K., Koenigs, Michael
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2015
• Subjects: Aged; Brain Injuries - complications; Brain Injuries - pathology; Brain Injuries - psychology; Cognition Disorders - diagnosis; Cognition Disorders - etiology; Decision Making - physiology; Decision-making; Female; Games, Experimental; Humans; Lesion; Male; Middle Aged; Neuroeconomics; Neuropsychological Tests; Prefrontal cortex; Prefrontal Cortex - physiopathology; Prospective Studies; Reaction Time - physiology; Risk-Taking; Statistics, Nonparametric; Decision-making; Neuroeconomics; Prefrontal cortex; Lesion
• ISSN: 0028-3932; 1873-3514; 1873-3514
• DOI: 10.1016/j.neuropsychologia.2015.10.026

One paradigmatic example of “irrational” bias in human economic decision-making—known as the “reflection effect”—is a tendency to prefer sure amounts over risky gambles in situations involving potential gain, but to prefer risky gambles over sure amounts in situations involving potential loss. To date, there is no causal evidence regarding the neural basis of the reflection effect. The ventromedial prefrontal cortex (vmPFC) is believed to play a critical role in mediating value-based decision-making. In this study, we administered a behavioral test of the reflection effect to three groups of subjects: neurosurgical patients with focal bilateral vmPFC lesions, neurosurgical patients with lesions outside vmPFC, and neurologically healthy adults. Subjects made a series of choices between a sure amount (e.g., gain of $50) and a gamble (e.g., 50% chance of gaining $100, 50% chance of gaining $0). Half the trials featured potential gains while the other half featured potential losses. The sure amounts varied across trials. Relative to the two comparison groups, the vmPFC lesion patients exhibited a significantly greater reflection effect; more gambles selected in the loss condition and fewer gambles selected in the gain condition. This finding demonstrates a critical role for vmPFC in governing susceptibility to bias in decision-making. •Reflection effect is a classic example of irrational bias in human decision-making.•Choice between sure amounts and risky gambles; gain and loss conditions.•vmPFC Lesion patients exhibited a greater reflection effect than normal subjects.•Less likely to gamble in gain conditions, more likely to gamble in loss conditions.