Immunological aspects in chronic lymphocytic leukemia (CLL) development

• Published in: Annals of hematology Vol. 91; no. 7; pp. 981 - 996
• Main Authors: García-Muñoz, Ricardo, Roldan Galiacho, Verónica, Llorente, Luis
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.07.2012; Springer Nature B.V
• Subjects: Anergy; Animals; Apoptosis; Autoantigens; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; B-Lymphocytes - physiology; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - physiology; Bone marrow; CD5 antigen; Cell activation; Cell Differentiation - genetics; Cell Differentiation - immunology; Cell survival; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - immunology; Chronic lymphatic leukemia; Development; Gene Expression Profiling; Germinal centers; Hematology; Humans; Immune Tolerance - genetics; Immune Tolerance - physiology; Immunoglobulins; Immunological aspects; Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis; Leukemia, Lymphocytic, Chronic, B-Cell - etiology; Leukemia, Lymphocytic, Chronic, B-Cell - immunology; Lymphocytes B; Malignancy; Medicine & Public Health; Models, Biological; Neoplastic Stem Cells - immunology; Neoplastic Stem Cells - physiology; Oncology; Pathogens; Review; Review Article; somatic hypermutation; Somatic Hypermutation, Immunoglobulin - genetics; Somatic Hypermutation, Immunoglobulin - physiology; Surface markers; Self-reactive B cells; Anergy; Clonal deletion; Receptor editing; Receptor revision; Memory B cell checkpoints; CD5+ expression

Chronic lymphocytic leukemia (CLL) is unique among B cell malignancies in that the malignant clones can be featured either somatically mutated or unmutated IGVH genes. CLL cells that express unmutated immunoglobulin variable domains likely underwent final development prior to their entry into the ge...