Mechanism of TH2/TH17-predominant and neutrophilic TH2/TH17-low subtypes of asthma

• Published in: Journal of allergy and clinical immunology Vol. 139; no. 5; pp. 1548 - 1558.e4
• Main Authors: Liu, Weimin, Liu, Sucai, Verma, Mukesh, Zafar, Iram, Good, James T., Rollins, Donald, Groshong, Stephen, Gorska, Magdalena M., Martin, Richard J., Alam, Rafeul
• Format: Journal Article
• Language: English
• Published: St. Louis Elsevier Inc 01.05.2017; Elsevier Limited
• Subjects: Allergy and Immunology; Alveoli; Asthma; Asthma endotype; Bronchus; C3a; Cell culture; Colonies; Colony-stimulating factor; Cytokines; Flow cytometry; Gene expression; Genotype & phenotype; Granulocyte colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; Growth factors; Helper cells; Human subjects; IL-1; infection; Inflammation; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 23; Interleukin 6; Interleukin 8; Kinases; Leukocytes (granulocytic); Leukocytes (neutrophilic); Lymphocytes; Lymphocytes T; MAP kinase; neutrophilic asthma; Peroxidase; Protein kinase; Smooth muscle; Subclinical infection; TH2/TH17-predominant asthma; Uric acid; β-Amyloid; C3a; infection; STAT; IL-1; TH2/TH17-predominant asthma; neutrophilic asthma; Asthma endotype; IL-1R; MAPK; BAL; G-CSF; DAMP; SAA; serum amyloid A; Th2/Th17-predominant asthma; IL1; danger-associated molecular pattern

The mechanism of TH2/TH17-predominant and TH2/TH17-low asthma is unknown. We sought to study the immune mechanism of TH2/TH17-predominant and TH2/TH17-low asthma. In a previously reported cohort of 60 asthmatic patients, 16 patients were immunophenotyped with TH2/TH17-predominant asthma and 22 patie...