Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy

• Published in: Redox biology Vol. 67; p. 102906
• Main Authors: Chu, Chengnan, Wang, Xinyu, Yang, Chao, Chen, Fang, Shi, Lin, Xu, Weiqi, Wang, Kai, Liu, Baochen, Wang, Chenyang, Sun, Dongping, Ding, Weiwei
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2023; Elsevier
• Subjects: Ferroptosis; Fundc1-dependent mitophagy; Intestinal ischemia reperfusion; Microvascular dysfunction; Neutrophil extracellular traps; Research Paper; Microvascular dysfunction; Intestinal ischemia reperfusion; Ferroptosis; Fundc1-dependent mitophagy; Neutrophil extracellular traps

Microvascular endothelial damage caused by intestinal ischemia‒reperfusion (II/R) is a primary catalyst for microcirculation dysfunction and enterogenous infection. Previous studies have mainly focused on how neutrophil extracellular traps (NETs) and ferroptosis cause intestinal epithelial injury, a...