Analysis of different innovative formulations of curcumin for improved relative oral bioavailability in human subjects

• Published in: European journal of nutrition Vol. 57; no. 3; pp. 929 - 938
• Main Authors: Purpura, Martin, Lowery, Ryan P., Wilson, Jacob M., Mannan, Haider, Münch, Gerald, Razmovski-Naumovski, Valentina
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2018; Springer Nature B.V
• Subjects: absorption; Adult; Antineoplastic Agents, Phytogenic - administration & dosage; Antineoplastic Agents, Phytogenic - blood; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - metabolism; Antioxidants - administration & dosage; Antioxidants - analysis; Antioxidants - chemistry; Antioxidants - metabolism; Area Under Curve; Bioavailability; Chemistry; Chemistry and Materials Science; Cohort Studies; Cross-Over Studies; Curcumin; Curcumin - administration & dosage; Curcumin - analogs & derivatives; Curcumin - analysis; Curcumin - chemistry; Curcumin - metabolism; Cyclodextrin; Diarylheptanoids; Dietary Supplements; dispersibility; Double-Blind Method; Essential oils; Female; Food Additives - chemistry; Food Handling; gamma-cyclodextrin; gamma-Cyclodextrins - chemistry; Human subjects; Humans; Intestinal Absorption; Intestine; Lipophilic; Male; Nutrition; Nutritive Value; Oral administration; Original Contribution; Pharmacokinetics; rhizomes; Solubility; turmeric; Young Adult; Cyclodextrin; Curcumin; Bioavailability; Plasma pharmacokinetics; Humans

Purpose The optimal health benefits of curcumin are limited by its low solubility in water and corresponding poor intestinal absorption. Cyclodextrins (CD) can form inclusion complexes on a molecular basis with lipophilic compounds, thereby improving aqueous solubility, dispersibility, and absorptio...