Cell type-specific localization of Ephs pairing with ephrin-B2 in the rat postnatal pituitary gland

• Published in: Cell and tissue research Vol. 370; no. 1; pp. 99 - 112
• Main Authors: Yoshida, Saishu, Kato, Takako, Kanno, Naoko, Nishimura, Naoto, Nishihara, Hiroto, Horiguchi, Kotaro, Kato, Yukio
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2017; Springer; Springer Nature B.V
• Subjects: adults; Animals; Biomedical and Life Sciences; Biomedicine; Cell membranes; Endothelial cells; Endothelial Cells - cytology; Endothelial Cells - metabolism; EphA4 protein; Ephrin-B2 - analysis; Ephrin-B2 - metabolism; Human Genetics; Immunohistochemistry; in situ hybridization; Localization; Molecular Medicine; niches; Parenchyma; Pituitary (anterior); Pituitary gland; Pituitary Gland - cytology; Pituitary Gland - growth & development; Pituitary Gland - metabolism; Pituitary Gland - ultrastructure; Pituitary hormones; Progenitor cells; Protein Interaction Maps; Proteomics; rats; Rats - growth & development; Rats - metabolism; Rats, Wistar; Receptor, EphB3 - analysis; Receptor, EphB3 - metabolism; Receptors, Eph Family - analysis; Receptors, Eph Family - metabolism; Regular Article; Rodents; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Niche; Rat pituitary; Ephrin-B2; Stem/progenitor cells; EphB3

Sox2 -expressing stem/progenitor cells in the anterior lobe of the pituitary gland form two types of micro-environments (niches): the marginal cell layer and dense cell clusters in the parenchyma. In relation to the mechanism of regulation of niches, juxtacrine signaling via ephrin and its receptor...