The Expression Regulation and Cancer-Promoting Roles of RACGAP1

• Published in: Biomolecules (Basel, Switzerland) Vol. 15; no. 1; p. 3
• Main Authors: Lin, Jiacheng, Zhu, Yuhao, Lin, Zhaoping, Yu, Jindong, Lin, Xiaobing, Lai, Weiyuan, Tong, Beibei, Xu, Liyan, Li, Enmin, Long, Lin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2025; MDPI
• Subjects: Animals; Apoptosis; Bioinformatics; Biomarkers; Breast cancer; Cancer; Cdc42 protein; Cell cycle; Cell division; Cell growth; Colorectal cancer; Cytokinesis; Cytoskeleton; Development and progression; Digestive system; Doxorubicin; ECT2; Gastric cancer; Gene Expression Regulation, Neoplastic; Genetic aspects; Germ cells; GTPase-activating protein; GTPase-Activating Proteins - genetics; GTPase-Activating Proteins - metabolism; Guanine nucleotide-binding protein; Humans; Insects; Kinases; Liver cancer; Mediation; Medical prognosis; Molecules; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Nuclear transport; Oncogenes; Oncology, Experimental; Ovarian cancer; Prostate; Proteins; RACGAP1; Respiratory system; Review; Rho-GTPases; rhoA GTP-Binding Protein - genetics; rhoA GTP-Binding Protein - metabolism; RhoA protein; Signal Transduction; STAT3; Stomach cancer; Therapeutic targets; Tumor suppressor genes; Rho-GTPases; RACGAP1; ECT2; STAT3

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form to the GDP-bound form. GAP has traditionally been known as a tumor suppressor. However, studies increasingly suggest that overexpressed RACGAP1 activates Rac...