Repurposing Astragalus Polysaccharide PG2 for Inhibiting ACE2 and SARS-CoV-2 Spike Syncytial Formation and Anti-Inflammatory Effects - Lee, Chia-Yin; Nguyen, Anh Thuc; Doan, Ly Hien; Chu, Li-Wei; Chang, Chih-Hung; Liu, Hui-Kang; Lee, I-Lin; Wang, Teng-Hsu; Lai, Jin-Mei; Tsao, Shih-Ming; Liao, Hsiu-Jung; Ping, Yueh-Hsin; et al. (Viruses, 2023)
Keywords: ACE2; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - metabolism; Anti-Inflammatory Agents - pharmacology; Astragalus membranaceus; Astragalus propinquus - chemistry; Cancer therapies; Cell activation; Cells; Coronaviruses; COVID-19; COVID-19 infection; Cytokine storm; Cytomegalovirus; Cytotoxicity; Drug Repositioning; Drug screening; drugs; Dyspnea; Epithelial cells; epithelium; FDA approval; Gene expression; Gene set enrichment analysis; genes; Genomes; giant cells; Humans; Immune system; Inflammation; Interleukin 1 receptors; Interleukin 10; Leukocytes (neutrophilic); lungs; Lymphocytes; macrophage activation; Macrophages; microRNA; MicroRNAs; Patients; phenotype; Phenotypes; Pneumonia; Polarization; Polysaccharides; Polysaccharides - pharmacology; Prescription drugs; Proteins; Public health; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - metabolism; Syncytia; therapeutics; viral entry; virus replication; United States--US; Taiwan; COVID-19; microRNAs; viral entry; macrophages; cytokine storm