Drug−disease interaction: Crohn's disease elevates verapamil plasma concentrations but reduces response to the drug proportional to disease activity - Sanaee, Forough; Clements, John D.; Waugh, Alistair W. G.; Fedorak, Richard N.; Lewanczuk, Richard; Jamali, Fakhreddin (British journal of clinical pharmacology, 2011)
Keywords: Adolescent; Adult; Antiarythmic agents; Area Under Curve; Biological and medical sciences; Calcium Channel Blockers - pharmacokinetics; Calcium Channel Blockers - pharmacology; calcium channels; Cardiovascular system; Case-Control Studies; Crohn Disease - metabolism; Crohn's disease; Drug Interactions; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; inflammation; Male; Medical sciences; Metabolic Clearance Rate; Middle Aged; Other diseases. Semiology; Pharmacokinetic Dynamic Relationships; Pharmacology. Drug treatments; PK−PD relationship; receptor down regulation; reduced response; Severity of Illness Index; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Verapamil - pharmacokinetics; Verapamil - pharmacology; Young Adult; Pharmacokinetic pharmacodynamic relationship; Calcium; calcium channels; Calcium antagonist; Pharmacotherapy; Ionic channel; Inorganic element; receptor down regulation; reduced response; Inflammatory disease; Activity concentration relation; Aralkylamine; Intestinal disease; Drug interaction; Biological receptor; Drug; Inflammation; Crohn's disease; Antiarrhythmic agent; PK-PD relationship; Biological activity; Crohn disease; Treatment; Digestive diseases; Verapamil; Pharmacokinetics