Dynamics and processivity of 40S ribosome scanning on mRNA in yeast

• Published in: Molecular microbiology Vol. 51; no. 4; pp. 987 - 1001
• Main Authors: Berthelot, Karine, Muldoon, Mark, Rajkowitsch, Lukas, Hughes, John, McCarthy, John E. G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.02.2004; Blackwell Science; Blackwell Publishing Ltd
• Subjects: 5' Untranslated Regions - physiology; Biological and medical sciences; Cell Cycle Proteins - physiology; Codon, Initiator - metabolism; DEAD-box RNA Helicases; Eukaryotic Initiation Factor-4A - physiology; Eukaryotic Initiation Factors - physiology; Fundamental and applied biological sciences. Psychology; Fungal Proteins - physiology; Microbiology; Peptide Chain Initiation, Translational; Protein Biosynthesis; ribosome 40S; Ribosomes - physiology; RNA Caps - metabolism; RNA Helicases - physiology; RNA, Bacterial - metabolism; RNA, Messenger - metabolism; Saccharomyces cerevisiae; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - physiology; Yeast; Messenger RNA; Microbiology; 40S-Ribosome

Summary The eukaryotic 40S ribosomal subunit locates the translation initiation codon on an mRNA via the so‐called scanning process that follows 40S binding to the capped 5′ end. This key step in translation is required for the expression of almost all eukaryotic genes, yet the mechanism and dynamic...