Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)

• Published in: Tissue antigens Vol. 47; no. 1; p. 37
• Main Authors: Yasunaga, S, Kimura, A, Hamaguchi, K, Ronningen, K S, Sasazuki, T
• Format: Journal Article
• Language: English
• Published: England 01.01.1996
• Subjects: Alleles; Base Sequence; Diabetes Mellitus, Type 1 - etiology; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Disease Susceptibility; Genes, MHC Class II; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; Humans; Immunity, Innate - genetics; Immunity, Innate - immunology; Japan; Linkage Disequilibrium; Molecular Sequence Data; Norway; Sequence Analysis, DNA; Norway; Japan

Previous studies have indicated that certain alleles of HLA-DR and -DQ genes were strongly associated with susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM), and the role of DQ molecule in IDDM has been suggested. To further clarify the association of DQ alleles with IDDM,...