Vasoconstrictor and vasodilator responses to tryptamine of rat‐isolated perfused mesentery: comparison with tyramine and β‐phenylethylamine

• Published in: British journal of pharmacology Vol. 165; no. 7; pp. 2191 - 2202
• Main Authors: Anwar, MA, Ford, WR, Broadley, KJ, Herbert, AA
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2012; Nature Publishing Group
• Subjects: 5‐HT receptors; Animals; Biological and medical sciences; In Vitro Techniques; Male; Medical sciences; Mesenteric Arteries - drug effects; Mesenteric Arteries - physiology; mesenteric vasculature; NG-Nitroarginine Methyl Ester - pharmacology; Perfusion; Pharmacology. Drug treatments; Phenethylamines - pharmacology; Phenylephrine - pharmacology; rat; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A - drug effects; Receptor, Serotonin, 5-HT2A - physiology; Receptors, Serotonin - drug effects; Receptors, Serotonin - physiology; Research Papers; Ritanserin - pharmacology; Serotonin - pharmacology; trace amines; trace amine‐associated receptors; tryptamine; Tryptamines - pharmacology; tyramine; Tyramine - pharmacology; Vasoconstriction - drug effects; Vasodilation - drug effects; β‐phenylethylamine; Tyramine; Tryptamine; Vasodilator agent; mesenteric vasculature; Rat; Rodentia; Vasoconstriction; Mesentery; Sympathomimetic; Serotonine receptor; trace amines; 5-HT receptors; Vascularization; trace amine-associated receptors; Vasomotricity; Vertebrata; Mammalia; Amine; β-phenylethylamine; Animal; Vasoconstrictor agent; Comparative study; Biological receptor

BACKGROUND AND PURPOSE Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the resistance arteries. Tryptamine interacts with trace amine‐associated receptors (TAARs) and because of its structural similarity to 5‐HT, it may a...