Prediction of functional profiles of gut microbiota from 16S rRNA metagenomic data provides a more robust evaluation of gut dysbiosis occurring in Japanese type 2 diabetic patients

• Published in: Journal of Clinical Biochemistry and Nutrition Vol. 61; no. 3; pp. 217 - 221
• Main Authors: Inoue, Ryo, Masuda, Shinya, Hasegawa, Koji, Inoue, Takayuki, Tsukahara, Takamitsu, Ohue-Kitano, Ryuji, Kusakabe, Toru, Tanaka, Masashi, Shimatsu, Akira, Satoh-Asahara, Noriko, Yamakage, Hajime
• Format: Journal Article
• Language: English
• Published: Japan SOCIETY FOR FREE RADICAL RESEARCH JAPAN 01.01.2017; Japan Science and Technology Agency; the Society for Free Radical Research Japan
• Subjects: Diabetes; Diabetes mellitus; Dysbacteriosis; dysbiosis; genus Blautia; glucose metabolism; Intestinal microflora; Original; prediction of functional profiles; rRNA 16S; prediction of functional profiles; diabetes; glucose metabolism; genus Blautia; dysbiosis
• ISSN: 0912-0009; 1880-5086
• DOI: 10.3164/jcbn.17-44

We assessed whether gut microbial functional profiles predicted from 16S rRNA metagenomics differed in Japanese type 2 diabetic patients. A total of 22 Japanese subjects were recruited from our outpatient clinic in an observational study. Fecal samples were obtained from 12 control and 10 type 2 dia...