Common pathogenetic mechanism involving human chromosome 18 in familial and sporadic ileal carcinoid tumors

• Published in: Genes chromosomes & cancer Vol. 50; no. 2; pp. 82 - 94
• Main Authors: Cunningham, Janet L., Díaz de Ståhl, Teresita, Sjöblom, Tobias, Westin, Gunnar, Dumanski, Jan P., Janson, Eva T.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.02.2011
• Subjects: Adult; Aged; Aged, 80 and over; Bacterial artificial chromosomes; Carcinoid Tumor - genetics; Carcinoid Tumor - metabolism; Carcinoid Tumor - pathology; Carcinoma; chromosome 18; chromosome 7; Chromosomes, Human, Pair 14 - genetics; Chromosomes, Human, Pair 18; Chromosomes, Human, Pair 7 - genetics; copy number; Etiology; Female; Gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Growth patterns; Heredity; Humans; Ileal Neoplasms - genetics; Ileal Neoplasms - metabolism; Ileal Neoplasms - pathology; Male; MEDICIN; MEDICINE; Metastases; Middle Aged; Mutation; Neoplasm Metastasis - genetics; Pedigree; Prognosis; Sequence Analysis; Serotonin; Single-nucleotide polymorphism; Small intestine; Telomeres; Tumor suppressor genes; Tumors; Young Adult

Serotonin producing endocrine carcinoma of small intestine (ileal carcinoid) is a clinically distinct endocrine tumor. It is generally considered as a sporadic disease and its molecular etiology is poorly understood. We report comprehensive clinical and molecular studies of 55 sporadic and familial...