FLT3 ligand regulates expansion of regulatory T-cells induced by regulatory dendritic cells isolated from gut-associated lymphoid tissues through the Notch pathway

• Published in: Chinese medical journal Vol. 138; no. 13; pp. 1595 - 1606
• Main Authors: Li, Na, Mao, Jingwei, Tang, Haiying, Tan, Xiaoyan, Bi, Jian, Wu, Hao, Chen, Xiuli, Wang, Yingde
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 05.07.2025; Lippincott Williams & Wilkins Ovid Technologies; Wolters Kluwer
• Subjects: Acids; Animals; Coculture Techniques; Colon; Dendritic cells; Dendritic Cells - cytology; Dendritic Cells - immunology; Dendritic Cells - metabolism; Flow Cytometry; Fluorides; Inflammatory bowel disease; Kinases; Laboratory animals; Ligands; Lymphatic system; Lymphocytes; Lymphoid Tissue - cytology; Lymphoid Tissue - immunology; Lymphoid Tissue - metabolism; Medical research; Membrane Proteins - metabolism; Mice; Mice, Inbred BALB C; Original; Receptors, Notch - metabolism; Signal Transduction - physiology; T-Lymphocytes, Regulatory - cytology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Beijing China; United States > US; China; Regulatory T-cells; Fms-like tyrosine kinase 3 ligand; Dendritic cells; Jagged1; Notch1

Abstract Background: Regulatory dendritic cell (DCreg) subset exhibits a unique capacity for inducing immune tolerance among the variety subsets of dendritic cells (DCs) within gut-associated lymphoid tissues (GALTs). Fms-like tyrosine kinase 3 ligand (FLT3L) is involved in the differentiation of DC...