Role of oxidative stress in the pathogenesis of oral submucous fibrosis: A preliminary prospective study
In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially...
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Published in | Contemporary clinical dentistry Vol. 6; no. Suppl 1; pp. S172 - S174 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
India
Medknow Publications and Media Pvt. Ltd
01.09.2015
Medknow Publications & Media Pvt. Ltd Medknow Publications & Media Pvt Ltd Wolters Kluwer Medknow Publications |
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Abstract | In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF.
Is to evaluate both antioxidant and oxidant status in OSMF and to compare with controls.
Twenty patients and 20 controls of the same age group were enrolled in the study.
Five milliliters of blood were collected from each individual and serum was separated. Malondialdehyde (MDA) estimation using thiobarbituric acid (TBA) method, and antioxidant activity (AOA) using principle of TBA reactive substances was done using this serum, with a calorimetric method.
Student's t-test and ANOVA test.
The mean serum AOA status was seen to significantly decrease in OSMF patients, as compared to controls (P = 0.013). The increase in mean serum MDA level was highly significant in OSMF patients, as compared to controls (P < 0.001).
The disparity between AOA and MDA levels in the patients clearly demonstrates the role of oxidative stress in the disease process. The results also suggest the use of antioxidants in the management of OSMF. |
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AbstractList | BACKGROUNDIn the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF. AIMSIs to evaluate both antioxidant and oxidant status in OSMF and to compare with controls. SETTINGS AND DESIGNTwenty patients and 20 controls of the same age group were enrolled in the study. SUBJECTS AND METHODSFive milliliters of blood were collected from each individual and serum was separated. Malondialdehyde (MDA) estimation using thiobarbituric acid (TBA) method, and antioxidant activity (AOA) using principle of TBA reactive substances was done using this serum, with a calorimetric method. STATISTICAL ANALYSIS USEDStudent's t-test and ANOVA test. RESULTSThe mean serum AOA status was seen to significantly decrease in OSMF patients, as compared to controls (P = 0.013). The increase in mean serum MDA level was highly significant in OSMF patients, as compared to controls (P < 0.001). CONCLUSIONThe disparity between AOA and MDA levels in the patients clearly demonstrates the role of oxidative stress in the disease process. The results also suggest the use of antioxidants in the management of OSMF. Background: In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF. Aims: Is to evaluate both antioxidant and oxidant status in OSMF and to compare with controls. Settings and Design: Twenty patients and 20 controls of the same age group were enrolled in the study. Subjects and Methods: Five milliliters of blood were collected from each individual and serum was separated. Malondialdehyde (MDA) estimation using thiobarbituric acid (TBA) method, and antioxidant activity (AOA) using principle of TBA reactive substances was done using this serum, with a calorimetric method. Statistical Analysis Used: Student's t-test and ANOVA test. Results: The mean serum AOA status was seen to significantly decrease in OSMF patients, as compared to controls (P = 0.013). The increase in mean serum MDA level was highly significant in OSMF patients, as compared to controls (P < 0.001). Conclusion: The disparity between AOA and MDA levels in the patients clearly demonstrates the role of oxidative stress in the disease process. The results also suggest the use of antioxidants in the management of OSMF. In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data suggests that reactive oxygen species play a key role in multistage carcinogenesis. Oral submucous fibrosis (OSMF) is considered as a potentially malignant disorder. Its increased incidence over recent years in the Indian subcontinent is a major health concern to oral physicians. However, the role of oxidative stress has not been widely investigated in OSMF. Is to evaluate both antioxidant and oxidant status in OSMF and to compare with controls. Twenty patients and 20 controls of the same age group were enrolled in the study. Five milliliters of blood were collected from each individual and serum was separated. Malondialdehyde (MDA) estimation using thiobarbituric acid (TBA) method, and antioxidant activity (AOA) using principle of TBA reactive substances was done using this serum, with a calorimetric method. Student's t-test and ANOVA test. The mean serum AOA status was seen to significantly decrease in OSMF patients, as compared to controls (P = 0.013). The increase in mean serum MDA level was highly significant in OSMF patients, as compared to controls (P < 0.001). The disparity between AOA and MDA levels in the patients clearly demonstrates the role of oxidative stress in the disease process. The results also suggest the use of antioxidants in the management of OSMF. |
Audience | Academic |
Author | Arunkumar, Shantala Shakunthala, G K Annigeri, Rajeshwari G |
AuthorAffiliation | Department of Oral Medicine and Radiology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India 1 Department of Oral Medicine and Radiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India 2 Department of Oral Medicine and Radiology, Sri Dharmasthala Manjunatheshwara College of Dental Sciences and Hospital, Dharwad, Karnataka, India |
AuthorAffiliation_xml | – name: 1 Department of Oral Medicine and Radiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India – name: Department of Oral Medicine and Radiology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India – name: 2 Department of Oral Medicine and Radiology, Sri Dharmasthala Manjunatheshwara College of Dental Sciences and Hospital, Dharwad, Karnataka, India |
Author_xml | – sequence: 1 givenname: G K surname: Shakunthala fullname: Shakunthala, G K organization: Department of Oral Medicine and Radiology, Mahe Institute of Dental Sciences and Hospital, Mahe, Puducherry, India – sequence: 2 givenname: Rajeshwari G surname: Annigeri fullname: Annigeri, Rajeshwari G organization: Department of Oral Medicine and Radiology, College of Dental Sciences and Hospital, Davangere, Karnataka, India – sequence: 3 givenname: Shantala surname: Arunkumar fullname: Arunkumar, Shantala organization: Department of Oral Medicine and Radiology, Sri Dharmasthala Manjunatheshwara College of Dental Sciences and Hospital, Dharwad, Karnataka, India |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26604570$$D View this record in MEDLINE/PubMed |
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Keywords | oral submucous fibrosis malondialdehyde Antioxidant activity oxidative stress |
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References_xml | – start-page: 204 volume-title: Effects of Vitamin E, ascorbic acid and mannitol on alloxan-induced lipid peroxidation in rats year: 1982 ident: key-10.4103/0976-237X.166823-3 publication-title: Arch Biochem Biophys contributor: fullname: Dillard – start-page: 203 volume-title: Role of lime in the generation of reactive oxygen species from betel-quid ingredients year: 1992 ident: key-10.4103/0976-237X.166823-1 publication-title: Environ Health Perspect contributor: fullname: Nair – start-page: 281 volume-title: Augmented heme oxygenase-1 expression in areca quid chewing-associated oral submucous fibrosis year: 2009 ident: key-10.4103/0976-237X.166823-7 publication-title: Oral Dis contributor: fullname: Tsai – start-page: 498 volume-title: Extracellular matrix remodeling in OSMF year: 2005 ident: key-10.4103/0976-237X.166823-2 publication-title: J Oral Pathol Med contributor: fullname: Utsunomiya – start-page: 138 volume-title: Role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis year: 2004 ident: key-10.4103/0976-237X.166823-5 publication-title: Indian J Clin Biochem contributor: fullname: Gupta – start-page: 256 issn: 0970-9290 volume-title: Expression of heat shock protein 70 in oral submucous fibrosis and oral squamous cell carcinoma: An immunohistochemical study year: 2011 ident: key-10.4103/0976-237X.166823-8 publication-title: Indian J Dent Res contributor: fullname: Thubashini – start-page: 23 issn: 0973-029X volume-title: An estimation of serum malondialdehyde, superoxide dismutase and Vitamin A in oral submucous fibrosis and its clinicopathologic correlation year: 2007 ident: key-10.4103/0976-237X.166823-6 publication-title: J Oral Maxillofac Pathol contributor: fullname: Metkari – start-page: 89 volume-title: Free radicals, antioxidants in disease and health year: 2008 ident: key-10.4103/0976-237X.166823-10 publication-title: Int J Biomed Sci contributor: fullname: Pham-Huy – start-page: 356 volume-title: Method for the measurement of antioxidant activity in human fluids year: 2001 ident: key-10.4103/0976-237X.166823-4 publication-title: J Clin Pathol contributor: fullname: Koracevic – start-page: 94 issn: 0970-9290 volume-title: Inducible nitric oxide synthase expression is upregulated in oral submucous fibrosis year: 2007 ident: key-10.4103/0976-237X.166823-9 publication-title: Indian J Dent Res contributor: fullname: Rajendran |
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Snippet | In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable data... Background: In the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology.... BACKGROUNDIn the current scenario pathogenesis of majority of the diseases is deeply linked with the oxidative stress, irrespective of its etiology. Enumerable... |
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SubjectTerms | Antioxidant activity Antioxidants Care and treatment Disease Fibrosis Free radicals Genetic aspects Lipid peroxidation malondialdehyde oral submucous fibrosis Original Oxidative stress Pathogenesis Physiological aspects Risk factors Rodents Studies |
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Title | Role of oxidative stress in the pathogenesis of oral submucous fibrosis: A preliminary prospective study |
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