Defects in CD4+ T cell LFA‐1 integrin‐dependent adhesion and proliferation protect Cd47−/− mice from EAE

• Published in: Journal of leukocyte biology Vol. 101; no. 2; pp. 493 - 505
• Main Authors: Azcutia, Veronica, Bassil, Ribal, Herter, Jan M., Engelbertsen, Daniel, Newton, Gail, Autio, Anu, Mayadas, Tanya, Lichtman, Andrew H., Khoury, Samia J., Parkos, Charles A., Elyaman, Wassim, Luscinskas, Francis W.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.02.2017; John Wiley and Sons Inc
• Subjects: Adhesion; Adoptive Transfer; Animals; Antibodies, Monoclonal - pharmacology; Antigen Presentation - drug effects; Antigen Presentation - immunology; Auditory defects; autoimmune; CD28 Antigens - metabolism; CD4 antigen; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD47 Antigen - metabolism; Cell activation; Cell adhesion; Cell Adhesion - drug effects; Cell proliferation; Cell Proliferation - drug effects; Chemokines - pharmacology; Crosslinking; Defects; Encephalomyelitis, Autoimmune, Experimental - immunology; Encephalomyelitis, Autoimmune, Experimental - pathology; Encephalomyelitis, Autoimmune, Experimental - prevention & control; Experimental allergic encephalomyelitis; Female; Glycoproteins; Homeostasis; Humans; Immunization; Inflammation, Extracellular Mediators, & Effector Molecules; Integrin alpha4beta1 - metabolism; Integrins; Intercellular Adhesion Molecule-1 - metabolism; LFA-1 antigen; Lymph Nodes - drug effects; Lymph Nodes - pathology; Lymphocyte Activation - drug effects; Lymphocyte Activation - immunology; Lymphocyte Function-Associated Antigen-1 - metabolism; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred C57BL; Myelin; Myelin-Oligodendrocyte Glycoprotein - immunology; neuroinflammation; Oligodendrocyte-myelin glycoprotein; Receptors, Antigen, T-Cell - metabolism; T cell receptors; T lymphocytes; TCR activation; Vascular Cell Adhesion Molecule-1 - metabolism; VLA-4 antigen; T lymphocytes; TCR activation; autoimmune; neuroinflammation

CD47 is known to play an important role in CD4+ T cell homeostasis. We recently reported a reduction in mice deficient in the Cd47 gene (Cd47−/−) CD4+ T cell adhesion and transendothelial migration (TEM) in vivo and in vitro as a result of impaired expression of high‐affinity forms of LFA‐1 and VLA‐...