Aberrant expressions of c-KIT and DOG-1 in mucinous and nonmucinous colorectal carcinomas and relation to clinicopathologic features and prognosis

• Published in: Annals of diagnostic pathology Vol. 19; no. 5; pp. 335 - 340
• Main Authors: Foda, Abd Al-Rahman Mohammad, PhD, Mohamed, Mie Ali, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2015
• Subjects: Adenocarcinoma, Mucinous - metabolism; Adult; Anoctamin-1; Biomarkers, Tumor - biosynthesis; c-KIT; Chloride Channels - biosynthesis; Colorectal; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Disease-Free Survival; DOG-1; Female; Humans; Immunohistochemistry; Male; Middle Aged; Mucinous; Neoplasm Proteins - biosynthesis; Pathology; Prognosis; Proto-Oncogene Proteins c-kit - biosynthesis; Retrospective Studies; Stem Cell Factor - metabolism; Tissue Array Analysis; Colorectal; Mucinous; DOG-1; c-KIT

Abstract c-KIT and DOG-1 are 2 highly expressed proteins in gastrointestinal stromal tumors. Few studies had investigated c-KIT, but not DOG-1, expression in colorectal carcinoma (CRC). This study aims to investigate expressions of c-KIT and DOG-1 in colorectal mucinous carcinoma and nonmucinous car...