Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer

• Published in: Frontiers in oncology Vol. 9; p. 858
• Main Authors: Feng, Qin, He, Bin
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 04.09.2019
• Subjects: androgen deprivation therapy (ADT); androgen receptor (AR); antiandrogen; castration-resistant prostate cancer (CRPC); Oncology; prostate cancer (PCa); small-cell prostate cancer (SCPC)

Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins demonstrated that the surgical removal of testes in men can result in a dramatic improvement in symptoms and can induce prostate...