De novo biosynthesis of the late endosome lipid, bis(monoacylglycero)phosphate

• Published in: Journal of lipid research Vol. 48; no. 9; pp. 1997 - 2008
• Main Authors: Hullin-Matsuda, Françoise, Kawasaki, Kiyoshi, Delton-Vandenbroucke, Isabelle, Xu, Yang, Nishijima, Masahiro, Lagarde, Michel, Schlame, Michael, Kobayashi, Toshihide
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 01.09.2007
• Subjects: Animals; Cardiomyopathy, Dilated - metabolism; CHO Cells; Cricetinae; Cricetulus; Humans; Life Sciences; Lysophospholipids - biosynthesis; Monoglycerides - biosynthesis; Transferases (Other Substituted Phosphate Groups) - deficiency

Bis(monoacylglycero)phosphate (BMP) is a unique lipid enriched in the late endosomes participating in the trafficking of lipids and proteins through this organelle. The de novo biosynthesis of BMP has not been clearly demonstrated. We investigated whether phosphatidylglycerol (PG) and cardiolipin (C...