Development and Clinical Applications of Therapeutic Cancer Vaccines with Individualized and Shared Neoantigens

• Published in: Vaccines (Basel) Vol. 12; no. 7; p. 717
• Main Authors: Hao, Qing, Long, Yuhang, Yang, Yi, Deng, Yiqi, Ding, Zhenyu, Yang, Li, Shu, Yang, Xu, Heng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.07.2024
• Subjects: Algorithms; Antigen (tumor-associated); Antigens; Bacteria; Bioinformatics; Cancer; cancer immunotherapy; Cancer vaccines; Complex formation; Complications and side effects; Diagnosis; Dosage and administration; Effectiveness; Genes; Haplotypes; Health aspects; Histocompatibility antigen HLA; Immune system; Immunogenicity; Immunotherapy; Lymphocytes; Medical research; Mutation; neoantigen; Neoantigens; Peptides; Prevention; Proteins; Therapeutic applications; therapeutic cancer vaccines; Tumor antigens; Tumors; Vaccines; China; neoantigen; cancer immunotherapy; therapeutic cancer vaccines

Neoantigens, presented as peptides on the surfaces of cancer cells, have recently been proposed as optimal targets for immunotherapy in clinical practice. The promising outcomes of neoantigen-based cancer vaccines have inspired enthusiasm for their broader clinical applications. However, the individ...