Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats
The aim of this study was to investigate the effects of proton pump inhibitor (PPI), the most potent acid-suppressing drug, administration and intake of a combination of yogurt and galactooligosaccharides (YG) on bone and mineral metabolism in adult rats. Twelve-week-old male Wistar rats were divide...
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Published in | Nutrients Vol. 8; no. 10; p. 653 |
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Language | English |
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Abstract | The aim of this study was to investigate the effects of proton pump inhibitor (PPI), the most potent acid-suppressing drug, administration and intake of a combination of yogurt and galactooligosaccharides (YG) on bone and mineral metabolism in adult rats. Twelve-week-old male Wistar rats were divided into three groups: a control group fed the control diet with vehicle administration, a PPI group fed the control diet with PPI administration and a YG + PPI group fed the YG diet with PPI administration. All of the groups received their respective experimental diets and daily subcutaneous injection of the vehicle or PPI for 12 weeks. The PPI group showed significantly lower bone mineral density (BMD) of the femur and the lumbar vertebrae and serum fibroblast growth factor 23 (FGF23) and significantly higher phosphorus absorption and serum 1,25-dihydroxyvitamin D (1,25(OH)2D) than the control group, although PPI did not affect calcium absorption. The PPI + YG group showed significantly higher BMD and serum FGF23 and significantly lower phosphorus absorption and serum 1,25(OH)2D than the PPI group. Furthermore, the PPI + YG group showed higher calcium absorption than the control group. These results suggest that although PPI administration did not affect calcium absorption, it adversely affected BMD and influenced phosphorus metabolism in adult rats. Furthermore, the YG diet beneficially affected BMD and attenuated the effects of PPI administration on phosphorus metabolism. |
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AbstractList | The aim of this study was to investigate the effects of proton pump inhibitor (PPI), the most potent acid-suppressing drug, administration and intake of a combination of yogurt and galactooligosaccharides (YG) on bone and mineral metabolism in adult rats. Twelve-week-old male Wistar rats were divided into three groups: a control group fed the control diet with vehicle administration, a PPI group fed the control diet with PPI administration and a YG + PPI group fed the YG diet with PPI administration. All of the groups received their respective experimental diets and daily subcutaneous injection of the vehicle or PPI for 12 weeks. The PPI group showed significantly lower bone mineral density (BMD) of the femur and the lumbar vertebrae and serum fibroblast growth factor 23 (FGF23) and significantly higher phosphorus absorption and serum 1,25-dihydroxyvitamin D (1,25(OH)2D) than the control group, although PPI did not affect calcium absorption. The PPI + YG group showed significantly higher BMD and serum FGF23 and significantly lower phosphorus absorption and serum 1,25(OH)2D than the PPI group. Furthermore, the PPI + YG group showed higher calcium absorption than the control group. These results suggest that although PPI administration did not affect calcium absorption, it adversely affected BMD and influenced phosphorus metabolism in adult rats. Furthermore, the YG diet beneficially affected BMD and attenuated the effects of PPI administration on phosphorus metabolism. |
Author | Yamaji, Taketo Shioyama, Miho Takasugi, Satoshi Nagata, Masashi Kitade, Masami |
AuthorAffiliation | Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan; miho.shioyama@meiji.com (M.S.); masami.kitade@meiji.com (M.K.); masashi.nagata@meiji.com (M.N.); taketo.yamaji@meiji.com (T.Y.) |
AuthorAffiliation_xml | – name: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan; miho.shioyama@meiji.com (M.S.); masami.kitade@meiji.com (M.K.); masashi.nagata@meiji.com (M.N.); taketo.yamaji@meiji.com (T.Y.) |
Author_xml | – sequence: 1 givenname: Satoshi surname: Takasugi fullname: Takasugi, Satoshi email: satoshi.takasugi@meiji.com organization: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. satoshi.takasugi@meiji.com – sequence: 2 givenname: Miho surname: Shioyama fullname: Shioyama, Miho email: miho.shioyama@meiji.com organization: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. miho.shioyama@meiji.com – sequence: 3 givenname: Masami surname: Kitade fullname: Kitade, Masami email: masami.kitade@meiji.com organization: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. masami.kitade@meiji.com – sequence: 4 givenname: Masashi surname: Nagata fullname: Nagata, Masashi email: masashi.nagata@meiji.com organization: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. masashi.nagata@meiji.com – sequence: 5 givenname: Taketo surname: Yamaji fullname: Yamaji, Taketo email: taketo.yamaji@meiji.com organization: Food Science Research Laboratories, Division of Research and Development, Meiji Co., Ltd., Odawara 250-0862, Japan. taketo.yamaji@meiji.com |
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CitedBy_id | crossref_primary_10_1080_03602532_2019_1610767 crossref_primary_10_1016_j_jtemb_2024_127446 crossref_primary_10_1016_j_jff_2020_103789 crossref_primary_10_3390_ijms231810733 crossref_primary_10_2147_DDDT_S287239 |
Cites_doi | 10.1271/bbb.69.1025 10.1271/bbb.59.236 10.1021/jf2009777 10.1007/s00223-006-0021-7 10.1016/j.mce.2011.05.038 10.1097/00004836-199000000-00010 10.3177/jnsv.41.95 10.1016/j.jnutbio.2012.07.004 10.1017/S0007114511002017 10.1016/S0271-5317(05)80780-8 10.3109/10408363.2010.536429 10.1079/BJN2000258 10.1097/00005176-198609000-00004 10.1172/JCI113886 10.1079/BJN20051552 10.1016/S0899-9007(99)00110-0 10.1093/ajcn/80.4.1066 10.1080/07315724.2002.10719216 10.1359/jbmr.2003.18.11.1978 10.1681/ASN.2011101006 10.1093/ajcn/77.2.449 10.1359/jbmr.2001.16.11.2152 10.1007/s00223-014-9855-6 10.1359/jbmr.061009 10.1093/ajcn/69.5.1014 10.1271/bbb.68.243 10.3177/jnsv.60.140 10.1359/jbmr.080803 10.1172/JCI108815 10.1152/physrev.00002.2011 10.1038/ki.2011.107 10.3748/wjg.v16.i19.2323 10.1001/jama.296.24.2947 10.1093/jn/132.11.3394 10.1007/s00394-004-0526-7 10.1016/j.bone.2013.09.014 10.1007/s00198-012-2112-9 10.1007/s12011-013-9681-0 10.1093/jn/130.12.2938 10.1111/j.1742-1241.2008.01883.x 10.1074/jbc.M408903200 10.1007/s11894-010-0141-0 10.1002/jbmr.1805 10.1007/s00394-009-0062-6 |
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Keywords | bone mineral density omeprazole calcitriol FGF23 proton pump inhibitor phosphorus |
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SubjectTerms | Animals Bone and Bones - drug effects Bone and Bones - metabolism Bone Density bone mineral density calcitriol Calcium, Dietary - blood Calcium, Dietary - pharmacology Dairy products Diet Femur - drug effects Femur - metabolism FGF23 Fibroblast Growth Factors - blood Food science Galactose Large intestine Lumbar Vertebrae - drug effects Lumbar Vertebrae - metabolism Male Metabolism Minerals - blood Nutrition research Oligosaccharides - pharmacology omeprazole Omeprazole - adverse effects Phosphorus Phosphorus - blood Proteins proton pump inhibitor Proton Pump Inhibitors - adverse effects Protons R&D Rats, Wistar Research & development Vitamin D - analogs & derivatives Vitamin D - blood Weaning Yogurt Yogurt - microbiology |
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Title | Effects of Proton Pump Inhibitor Administration and Intake of a Combination of Yogurt and Galactooligosaccharides on Bone and Mineral Metabolism in Rats |
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