Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice

• Published in: Environmental health perspectives Vol. 125; no. 10; p. 107006
• Main Authors: Chappell, Grace A, Israel, Jennifer W, Simon, Jeremy M, Pott, Sebastian, Safi, Alexias, Eklund, Karl, Sexton, Kenneth G, Bodnar, Wanda, Lieb, Jason D, Crawford, Gregory E, Rusyn, Ivan, Furey, Terrence S
• Format: Journal Article
• Language: English
• Published: United States National Institute of Environmental Health Sciences 01.10.2017; Environmental Health Perspectives
• Subjects: 1,3-Butadiene; Accessibility; Annotations; Bioinformatics; Butadiene; Cancer; Cancer genetics; Carcinogens; Chemical carcinogenesis; Chemical damage; Chromatin; Data processing; Deoxyribonucleic acid; Detoxification; DNA; DNA damage; DNA methylation; Environmental effects; Environmental toxicology; Exposure; Gene expression; Genes; Genetic diversity; Genomes; Health aspects; In vivo methods and tests; Inbreeding; Laboratories; Lungs; Measurement methods; Metabolism; Mice; MicroRNAs; miRNA; Mitochondrial DNA; Molecular chains; Ribonucleic acid; RNA; Toxicants; Toxicology; Transcription; Transcription (Genetics); Transcription factors; Tumors; United States

The damaging effects of exposure to environmental toxicants differentially affect genetically distinct individuals, but the mechanisms contributing to these differences are poorly understood. Genetic variation affects the establishment of the gene regulatory landscape and thus gene expression, and w...