Different Metabolites of the Gastric Mucosa between Patients with Current Helicobacter pylori Infection, Past Infection, and No Infection History

• Published in: Biomedicines Vol. 10; no. 3; p. 556
• Main Authors: Son, Su-Young, Lee, Choong-Hwan, Lee, Sun-Young
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.02.2022; MDPI
• Subjects: Alcohols; Amino acids; Biopsy; Carcinogenesis; Chromatography; Data processing; Discriminant analysis; Endoscopy; Fatty acids; Gas chromatography; Gastric cancer; Gastric mucosa; Gastroscopy; Helicobacter pylori; Infections; Lipid metabolism; Mass spectrometry; Mass spectroscopy; Metabolism; Metabolites; Organic acids; Scientific imaging; Serology; Software; Statistical analysis; Variables; Variance analysis; United States > US; Japan; gastric mucosa; Helicobacter pylori; gas chromatography; metabolites
• DOI: 10.3390/biomedicines10030556
• ISSN: 2227-9059

( ) alters metabolism during the gastric carcinogenesis process. This study aimed to determine the metabolites in the gastric mucosa according to the status of the infection. Patients who visited the outpatient clinic for a gastroscopy and tests were included. Gas chromatography-time-of-flight mass spectrometry (GC-TOF-MS) analysis was performed using gastric biopsied specimens from the corpus. Twenty-eight discriminative metabolites were found in the gastric mucosa of 10 patients with current infection, in 15 with past infection, and in five with no infection history. The relative abundances (RAs) of amino acids and sugars/sugar alcohols were higher in patients with no infection history than in patients with current or past infection. The current infection group showed higher RAs of organic acids and lower RAs of fatty acids and lipids compared with the other groups. The RA of inosine was highest in the past infection group. Based on GC-TOF-MS analysis findings, metabolites differed not only between the infected and non-infected patients, but also between those with and without infection history. Amino acid and sugars/sugar alcohol metabolites decreased in patients with current or past infection, whereas fatty acid and lipid metabolites decreased only during current infection.