Potential risk factors of susceptibility to recurrent depression

• Published in: Brain research bulletin Vol. 227; p. 111374
• Main Authors: Wang, Shuzhuo, Guo, Lei, Wang, Chuang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2025; Elsevier
• Subjects: Adult; Animals; BICC1; Depression - metabolism; Depressive Disorder, Major - blood; Depressive Disorder, Major - metabolism; Disease Models, Animal; Disease Susceptibility; Female; HIF1α; HSP90; HSP90 Heat-Shock Proteins - blood; HSP90 Heat-Shock Proteins - metabolism; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - blood; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Major depressive disorder (MDD); Male; Mice; Mice, Inbred C57BL; Middle Aged; Prefrontal Cortex - metabolism; Recurrence; Recurrent depression; Risk Factors; Stress, Psychological - metabolism; HSP90; HIF1α; Recurrent depression; BICC1; Major depressive disorder (MDD)

Major depressive disorder (MDD) is a highly prevalent and recurrent neuropsychiatric disorder associated with alterations in the BicC family RNA binding protein 1 (BICC1). However, the potential risk factors that regulate BICC1 and affect susceptibility to recurrent depression remain unclear. Herein...