Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current platelet aggregation inhibitors, including GPIIb/IIIa receptor antagonists, and anticoagulants is counterbalanced by the risk of intracerebral ble...

Full description

Saved in:
Bibliographic Details
Published inBlood Vol. 112; no. 9; pp. 3555 - 3562
Main Authors Stoll, Guido, Kleinschnitz, Christoph, Nieswandt, Bernhard
Format Journal Article
LanguageEnglish
Published Washington, DC Elsevier Inc 01.11.2008
Americain Society of Hematology
Subjects
Animals
Anticoagulants - therapeutic use
Biological and medical sciences
Blood Coagulation
Blood Platelets - physiology
Brain Ischemia - complications
Brain Ischemia - physiopathology
Brain Ischemia - therapy
Disease Models, Animal
Hematologic and hematopoietic diseases
Humans
Intracranial Thrombosis - complications
Intracranial Thrombosis - physiopathology
Intracranial Thrombosis - therapy
Medical sciences
Neurology
Platelet Aggregation Inhibitors - therapeutic use
Platelet Membrane Glycoproteins - physiology
Stroke - etiology
Stroke - physiopathology
Stroke - prevention & control
Stroke - therapy
Thrombolytic Therapy
Vascular diseases and vascular malformations of the nervous system
Cerebral infarction
Nervous system diseases
Stroke
Hematology
Targeted therapy
Thrombus
Cardiovascular disease
Mechanism
Cerebral disorder
Vascular disease
Central nervous system disease
Brain ischemia
Cerebrovascular disease
Online AccessGet full text

Cover

Abstract In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current platelet aggregation inhibitors, including GPIIb/IIIa receptor antagonists, and anticoagulants is counterbalanced by the risk of intracerebral bleeding complications. Numerous attempts to establish neuroprotection in ischemic stroke have been unfruitful. Thus, there is strong demand for novel treatment strategies. Major advances have been made in understanding the molecular functions of platelet receptors such as glycoprotein Ib (GPIb) and GPVI and their downstream signaling pathways that allow interference with their function. Inhibition of these receptors in the mouse stroke model of transient middle cerebral artery occlusion prevented infarctions without increasing the risk of intracerebral bleeding. Similarly, it is now clear that the intrinsic coagulation factor XII (FXII) and FXI play a functional role in thrombus formation and stabilization during stroke: their deficiency or blockade protects from cerebral ischemia without overtly affecting hemostasis. Based on the accumulating evidence that thrombus formation and hemostasis are not inevitably linked, new concepts for prevention and treatment of ischemic stroke may eventually emerge without the hazard of severe bleeding complications. This review discusses recent advances related to antithrombotic strategies in experimental stroke research.
AbstractList In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current platelet aggregation inhibitors, including GPIIb/IIIa receptor antagonists, and anticoagulants is counterbalanced by the risk of intracerebral bleeding complications. Numerous attempts to establish neuroprotection in ischemic stroke have been unfruitful. Thus, there is strong demand for novel treatment strategies. Major advances have been made in understanding the molecular functions of platelet receptors such as glycoprotein Ib (GPIb) and GPVI and their downstream signaling pathways that allow interference with their function. Inhibition of these receptors in the mouse stroke model of transient middle cerebral artery occlusion prevented infarctions without increasing the risk of intracerebral bleeding. Similarly, it is now clear that the intrinsic coagulation factor XII (FXII) and FXI play a functional role in thrombus formation and stabilization during stroke: their deficiency or blockade protects from cerebral ischemia without overtly affecting hemostasis. Based on the accumulating evidence that thrombus formation and hemostasis are not inevitably linked, new concepts for prevention and treatment of ischemic stroke may eventually emerge without the hazard of severe bleeding complications. This review discusses recent advances related to antithrombotic strategies in experimental stroke research.
Author Kleinschnitz, Christoph
Nieswandt, Bernhard
Stoll, Guido
Author_xml – sequence: 1
  givenname: Guido
  surname: Stoll
  fullname: Stoll, Guido
  email: stoll_g@klinik.uni-wuerzburg.de
  organization: Department of Neurology, University of Würzburg, Würzburg, Germany
– sequence: 2
  givenname: Christoph
  surname: Kleinschnitz
  fullname: Kleinschnitz, Christoph
  organization: Department of Neurology, University of Würzburg, Würzburg, Germany
– sequence: 3
  givenname: Bernhard
  surname: Nieswandt
  fullname: Nieswandt, Bernhard
  email: bernhard.nieswandt@virchow.uni-wuerzburg.de
  organization: Rudolf Virchow Center, Deutsche Forschungsgemeinschaft (DFG) Research Center for Experimental Biomedicine, University of Würzburg, Würzburg, Germany
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20804485$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/18676880$$D View this record in MEDLINE/PubMed
BookMark eNp9kE2LFDEQhoOsuLOr_0AkF721VjLpTtaDsCx-wYoXPYfqdPVMtJOsSXrBf29mZ9CbUFBQ9bxF8Vyws5giMfZcwGshjHwzLilNnQQwHahOKKV784htRC_bACScsQ0ADJ260uKcXZTyA0CoreyfsHNhBj0YAxu2-5IWcuuCmQdye4y-hMLTzOs-pzCuhc8pB6w-Re5bFben4B0vNaef9JbHdE9L2xS_29fCMU68Yt5RfQjymglroFifssczLoWenfol-_7h_bebT93t14-fb65vO9eDrB0JcNsJZ-ValzQPipQ2E-GIhMpoMRjlBt2PJI2WOKDG0ZihVwdU0LS9ZK-Od-9y-rVSqTa0n2lZMFJaix2uNEgttg1UR9DlVEqm2d5lHzD_tgLsQbB9EGwPgi0oexTcYi9O99cx0PQvdDLagJcnAIvDZc4YnS9_OQkGlDJ9494dOWo27j1lW5yn6GjymVy1U_L__-QPnRSd6A
CitedBy_id crossref_primary_10_1182_blood_2008_09_180695
crossref_primary_10_1039_c1ob05478c
crossref_primary_10_1182_blood_2011_08_372193
crossref_primary_10_1002_ana_25352
crossref_primary_10_1161_ATVBAHA_121_316108
crossref_primary_10_4196_kjpp_2021_25_1_59
crossref_primary_10_1016_j_bbi_2020_12_027
crossref_primary_10_1161_ATVBAHA_112_250993
crossref_primary_10_1002_ana_24380
crossref_primary_10_1039_c2ob26511g
crossref_primary_10_1161_STROKEAHA_115_011238
crossref_primary_10_1161_CIRCULATIONAHA_118_034600
crossref_primary_10_3389_fphar_2023_1220862
crossref_primary_10_1093_cvr_cvx071
crossref_primary_10_1016_j_jconrel_2015_06_021
crossref_primary_10_1007_s00018_015_1845_y
crossref_primary_10_1016_j_csbj_2014_11_008
crossref_primary_10_1155_2018_2596043
crossref_primary_10_3390_ijms23020907
crossref_primary_10_1111_j_1538_7836_2011_04361_x
crossref_primary_10_1371_journal_pone_0018386
crossref_primary_10_1371_journal_pone_0110776
crossref_primary_10_18087_cardio_2019_6_n686
crossref_primary_10_1016_j_abb_2019_108193
crossref_primary_10_1161_STROKEAHA_117_018839
crossref_primary_10_1182_blood_2012_03_419523
crossref_primary_10_1016_j_brainres_2017_02_011
crossref_primary_10_1111_j_1538_7836_2012_04924_x
crossref_primary_10_1002_ddr_21114
crossref_primary_10_1016_j_biopha_2016_11_125
crossref_primary_10_1111_bjh_13990
crossref_primary_10_1515_rams_2019_0024
crossref_primary_10_2147_IJN_S462194
crossref_primary_10_1021_acsnano_9b01798
crossref_primary_10_3343_alm_2018_38_5_413
crossref_primary_10_3892_mmr_2014_2696
crossref_primary_10_1007_s00109_010_0691_5
crossref_primary_10_1161_STROKEAHA_119_025357
crossref_primary_10_1177_15910199211028342
crossref_primary_10_1016_j_biocel_2018_09_011
crossref_primary_10_1111_jth_12293
crossref_primary_10_1161_ATVBAHA_110_208918
crossref_primary_10_1007_s00115_011_3368_6
crossref_primary_10_1155_2013_608430
crossref_primary_10_1007_s12185_016_2086_z
crossref_primary_10_3892_mmr_2017_8253
crossref_primary_10_1039_D2BM02013K
crossref_primary_10_1371_journal_pone_0058979
crossref_primary_10_1161_STROKEAHA_110_602532
crossref_primary_10_1007_s12975_016_0501_7
crossref_primary_10_1371_journal_pone_0101209
crossref_primary_10_1160_THS10_11_0720
crossref_primary_10_5482_HAMO_14_11_0071
crossref_primary_10_1002_anie_202010391
crossref_primary_10_1038_jcbfm_2012_108
crossref_primary_10_1016_j_pathophys_2009_12_001
crossref_primary_10_1111_j_1749_6632_2010_05730_x
crossref_primary_10_1186_2040_7378_3_9
crossref_primary_10_1155_2014_430757
crossref_primary_10_1016_j_bmcl_2011_05_082
crossref_primary_10_1016_j_ijcard_2016_06_104
crossref_primary_10_3892_mmr_2017_7556
crossref_primary_10_1016_j_ebiom_2022_104275
crossref_primary_10_1111_j_1538_7836_2009_03455_x
crossref_primary_10_3390_jcm9040996
crossref_primary_10_1002_ange_202010391
crossref_primary_10_1016_j_resp_2010_01_010
crossref_primary_10_1182_blood_2016_12_750711
crossref_primary_10_1182_blood_2009_10_249078
crossref_primary_10_1155_2015_876426
crossref_primary_10_1160_TH13_02_0102
crossref_primary_10_2174_1573413715666191111111718
crossref_primary_10_1111_jth_14215
crossref_primary_10_1016_j_jep_2020_113212
crossref_primary_10_1113_jphysiol_2011_212886
crossref_primary_10_1371_journal_pone_0119810
crossref_primary_10_1111_j_1747_4949_2012_00770_x
crossref_primary_10_1182_blood_2014_06_580597
crossref_primary_10_2337_dc09_1518
crossref_primary_10_1007_s00018_022_04257_7
crossref_primary_10_1016_j_jep_2014_03_056
crossref_primary_10_1136_svn_2019_000302
crossref_primary_10_1111_j_1538_7836_2011_04269_x
crossref_primary_10_1161_STROKEAHA_111_628867
crossref_primary_10_1002_adhm_202102059
crossref_primary_10_1161_ATVBAHA_110_212316
crossref_primary_10_1161_ATVBAHA_116_308622
crossref_primary_10_1161_CIRCULATIONAHA_109_924761
crossref_primary_10_3390_ijms21186539
crossref_primary_10_1016_j_fct_2022_113419
crossref_primary_10_1186_2040_7378_2_5
crossref_primary_10_1160_TH11_10_0745
crossref_primary_10_1172_jci_insight_86460
crossref_primary_10_1182_blood_2012_10_461459
crossref_primary_10_1016_j_patbio_2013_11_002
crossref_primary_10_1182_blood_2012_06_440057
crossref_primary_10_1159_000368434
crossref_primary_10_1186_s12959_016_0100_6
crossref_primary_10_1161_ATVBAHA_114_304530
crossref_primary_10_1182_blood_2015_05_646117
crossref_primary_10_3892_mmr_2016_5146
crossref_primary_10_1016_j_nut_2012_03_015
crossref_primary_10_1371_journal_pone_0011658
crossref_primary_10_1182_blood_2009_12_255000
crossref_primary_10_3109_09537100903528269
crossref_primary_10_1007_s11596_018_1896_z
crossref_primary_10_1038_aps_2010_186
crossref_primary_10_1172_JCI69210
crossref_primary_10_1160_TH13_02_0096
crossref_primary_10_1515_bc_2010_081
crossref_primary_10_1016_j_brainres_2018_11_010
crossref_primary_10_1161_STROKEAHA_113_004111
crossref_primary_10_1111_jth_15486
crossref_primary_10_1080_13543776_2021_1945580
crossref_primary_10_1172_JCI71245
crossref_primary_10_1016_j_ceca_2011_04_002
crossref_primary_10_1016_j_bbi_2009_09_010
crossref_primary_10_3389_fimmu_2022_843404
crossref_primary_10_1007_s12031_020_01545_4
crossref_primary_10_1093_jnen_nly032
crossref_primary_10_1126_scisignal_2000551
crossref_primary_10_1111_j_1365_2141_2010_08382_x
crossref_primary_10_1161_STROKEAHA_112_660340
crossref_primary_10_1016_j_bcp_2020_114057
crossref_primary_10_1016_j_addr_2021_113832
crossref_primary_10_1016_j_thromres_2018_08_005
crossref_primary_10_1517_14728222_2012_715149
crossref_primary_10_1161_ATVBAHA_117_310294
crossref_primary_10_1007_s12035_024_04039_1
crossref_primary_10_1002_VIW_20200137
crossref_primary_10_1016_j_pneurobio_2012_11_004
crossref_primary_10_3390_biom9060217
crossref_primary_10_1007_s11239_024_02974_3
crossref_primary_10_1161_ATVBAHA_112_300916
crossref_primary_10_1016_j_jmgm_2012_04_002
crossref_primary_10_1182_blood_2009_06_230110
crossref_primary_10_1161_ATVBAHA_122_318115
crossref_primary_10_1016_j_bbrc_2021_03_171
crossref_primary_10_1007_s00109_011_0812_9
crossref_primary_10_1016_j_bmcl_2015_06_090
crossref_primary_10_1080_14737175_2017_1395700
crossref_primary_10_3389_fphar_2018_01155
crossref_primary_10_1371_journal_pone_0099851
crossref_primary_10_3390_antiox9090857
crossref_primary_10_1161_ATVBAHA_113_302030
crossref_primary_10_1016_j_jstrokecerebrovasdis_2013_05_001
crossref_primary_10_1182_blood_2016_09_740670
crossref_primary_10_1038_s41467_019_13343_7
crossref_primary_10_1111_bph_13178
crossref_primary_10_1002_jcla_24361
crossref_primary_10_1007_s00249_009_0492_3
crossref_primary_10_4103_bc_BC_5_18
crossref_primary_10_1111_j_1755_5949_2012_00340_x
crossref_primary_10_3390_ijms18081638
crossref_primary_10_5482_HAMO_14_10_0049
crossref_primary_10_1016_j_jff_2022_105138
crossref_primary_10_1073_pnas_0906436106
crossref_primary_10_1016_j_neuroimage_2009_11_061
Cites_doi 10.1074/jbc.274.41.29019
10.1161/01.STR.25.1.202
10.1046/j.1538-7836.2003.00267.x
10.1016/S1474-4422(06)70412-4
10.1111/j.1538-7836.2007.02446.x
10.1084/jem.193.4.459
10.1097/01.WCB.0000132690.96836.7F
10.1161/01.STR.31.6.1402
10.1161/STROKEAHA.107.496448
10.1084/jem.20080302
10.1056/NEJM199512143332401
10.1084/jem.20071800
10.1212/WNL.51.3_Suppl_3.S9
10.1016/S0006-8993(01)02735-4
10.1038/nm1722
10.1161/01.STR.23.4.552
10.1111/j.1538-7836.2007.02482.x
10.1182/blood-2007-10-120139
10.1212/01.WNL.0000129480.17345.4A
10.1161/01.STR.0000254600.92975.1f
10.1073/pnas.74.12.5260
10.1073/pnas.0608207103
10.1160/TH07-08-0508
10.1161/01.STR.0000226901.34927.10
10.3171/jns.2006.105.4.595
10.1016/j.thromres.2004.07.020
10.1172/JCI118392
10.1016/j.brainres.2007.07.103
10.1073/pnas.050582097
10.1002/cyto.10114
10.1084/jem.20071827
10.1016/S0140-6736(07)61778-4
10.1021/jm8002697
10.1161/STROKEAHA.107.496281
10.2174/138161208783497688
10.1161/01.STR.0000018081.33541.E3
10.1161/01.STR.0000165918.80812.1e
10.1161/01.STR.25.9.1847
10.1111/j.1365-2516.2006.01304.x
10.1055/s-2007-1002658
10.1161/01.STR.30.1.134
10.1161/01.STR.0000185730.50480.e7
10.1073/pnas.0608647104
10.1001/jama.284.12.1549
10.1172/JCI119500
10.1016/S0140-6736(97)04010-5
10.1161/01.STR.0000254622.52483.03
10.1161/STROKEAHA.107.487520
10.1159/000086100
10.1161/01.STR.0000163257.66207.2d
10.1016/S0140-6736(96)09457-3
10.1016/S1474-4422(03)00266-7
10.1182/blood-2003-05-1391
10.1084/jem.20020945
10.1016/S0166-2236(99)01401-0
10.1161/CIRCULATIONAHA.107.691279
10.1161/CIRCULATIONAHA.105.539221
10.1084/jem.190.1.91
10.1161/01.STR.0000170642.39876.f2
10.1093/qjmed/hci014
10.1182/blood-2007-11-123620
10.1016/S0092-8674(00)80983-6
10.1212/01.WNL.0000063323.23493.98
10.1182/blood-2002-12-3882
10.1161/01.STR.31.3.582
10.1055/s-0037-1616216
10.1182/blood.V99.10.3623
10.1161/01.ATV.0000130465.23430.74
10.1161/01.RES.0000261936.85776.5f
10.1084/jem.20050664
10.1038/nri2152
10.1084/jem.20052458
10.1161/STROKEAHA.107.181486
10.1161/STROKEAHA.106.476648
10.1084/jem.20060217
10.1002/ana.20741
10.1016/S1474-4422(07)70079-0
10.1160/TH06-06-0297
10.1172/JCI3338
10.1172/JCI32312
10.1038/nm1098
10.1016/S0140-6736(01)05837-8
10.1161/STROKEAHA.107.507228
10.1097/01.WCB.0000078322.96027.78
10.1161/01.STR.0000258356.68323.6d
10.1161/hs0302.104628
10.1001/jama.279.16.1265
10.1161/01.STR.0000244767.39962.f7
10.1016/S0140-6736(97)04011-7
10.1084/jem.190.6.803
10.1016/S0140-6736(06)68770-9
10.1161/01.STR.0000179043.73314.4f
10.1161/01.STR.0000198808.90579.65
ContentType Journal Article
Copyright 2008 American Society of Hematology
2009 INIST-CNRS
Copyright_xml – notice: 2008 American Society of Hematology
– notice: 2009 INIST-CNRS
DBID 6I.
AAFTH
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
DOI 10.1182/blood-2008-04-144758
DatabaseName ScienceDirect Open Access Titles
Elsevier:ScienceDirect:Open Access
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
MEDLINE - Academic
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
MEDLINE - Academic
DatabaseTitleList
MEDLINE
CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
Anatomy & Physiology
EISSN 1528-0020
EndPage 3562
ExternalDocumentID 10_1182_blood_2008_04_144758
18676880
20804485
S0006497120519137
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
-~X
.55
1CY
23N
2WC
34G
39C
4.4
53G
5GY
5RE
5VS
6I.
6J9
9M8
AAEDW
AAFTH
AAXUO
ABOCM
ABVKL
ACGFO
ADBBV
AENEX
AFFNX
AFOSN
AHPSJ
ALMA_UNASSIGNED_HOLDINGS
BAWUL
BTFSW
C1A
CS3
DIK
DU5
E3Z
EBS
EJD
EX3
F5P
FDB
FRP
GS5
GX1
IH2
K-O
KQ8
L7B
LSO
MJL
N4W
N9A
OK1
P2P
R.V
RHF
RHI
ROL
SJN
THE
TR2
TWZ
W2D
W8F
WH7
WOQ
WOW
X7M
YHG
YKV
ZA5
ZGI
.GJ
08R
AAQQT
AAUGY
ABPTK
AI.
AMRAJ
H13
IQODW
J5H
MVM
OHT
UCJ
VH1
WHG
ZXP
0R~
0SF
AALRI
ADVLN
AITUG
AKRWK
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7X8
ID FETCH-LOGICAL-c502t-e10c3daf4c0c32ef64e478deabaea4871684c675be2872a6a7ab88654ef641ed3
IEDL.DBID ABVKL
ISSN 0006-4971
IngestDate Fri Oct 25 08:26:00 EDT 2024
Fri Aug 23 03:25:30 EDT 2024
Sat Sep 28 08:40:18 EDT 2024
Sun Oct 22 16:08:58 EDT 2023
Fri Feb 23 02:45:40 EST 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 9
Keywords Cerebral infarction
Nervous system diseases
Stroke
Hematology
Targeted therapy
Thrombus
Cardiovascular disease
Mechanism
Cerebral disorder
Vascular disease
Central nervous system disease
Brain ischemia
Cerebrovascular disease
Language English
License This article is made available under the Elsevier license.
CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c502t-e10c3daf4c0c32ef64e478deabaea4871684c675be2872a6a7ab88654ef641ed3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
OpenAccessLink https://www.sciencedirect.com/science/article/pii/S0006497120519137
PMID 18676880
PQID 69702713
PQPubID 23479
PageCount 8
ParticipantIDs proquest_miscellaneous_69702713
crossref_primary_10_1182_blood_2008_04_144758
pubmed_primary_18676880
pascalfrancis_primary_20804485
elsevier_sciencedirect_doi_10_1182_blood_2008_04_144758
PublicationCentury 2000
PublicationDate 2008-11-01
PublicationDateYYYYMMDD 2008-11-01
PublicationDate_xml – month: 11
  year: 2008
  text: 2008-11-01
  day: 01
PublicationDecade 2000
PublicationPlace Washington, DC
PublicationPlace_xml – name: Washington, DC
– name: United States
PublicationTitle Blood
PublicationTitleAlternate Blood
PublicationYear 2008
Publisher Elsevier Inc
Americain Society of Hematology
Publisher_xml – name: Elsevier Inc
– name: Americain Society of Hematology
References Feske (bib85) 2007; 7
Mackman (bib89) 2004; 24
O'Collins, Macleod, Donnan, Horky, van der Worp, Howells (bib8) 2006; 59
(bib14) 1997; 349
Adams, del Zoppo, Alberts (bib16) 2007; 38
Varga-Szabo, Braun, Kleinschnitz (bib87) 2008; 205
Choudhri, Hoh, Zerwes (bib46) 1998; 102
Choi, Bateman, Mangla (bib10) 2006; 37
(bib17) 1996; 348
Massberg, Schürzinger, Lorenz (bib61) 2005; 112
Nieswandt, Moser, Pleines (bib22) 2007; 204
Mocco, Mack, Ducruet (bib96) 2006; 105
Sachs, Nieswandt (bib54) 2007; 100
Okada, Copeland, Fitridge, Koziol, del Zoppo (bib53) 1994; 25
Gubitz, Sandercock, Counsell (bib41) 2004; 3
Salomon, Steinberg, Seligsohn (bib93) 2006; 12
Zhang, Zhang, Tsang (bib47) 2001; 912
Nieswandt, Watson (bib79) 2003; 102
Sandercock, Gubitz, Foley, Counsell (bib19) 2008; 2
Hart, Tonarellin, Pearce (bib42) 2005; 36
Massberg, Gawaz, Grüner (bib66) 2003; 197
Orset, Macrez, Young (bib52) 2007; 38
Eckert, Koch, Thomalla (bib28) 2005; 36
Grüner, Prostredna, Schulte (bib83) 2003; 102
Coleman (bib95) 2006; 203
Moser, Nieswandt, Ussar, Pozgajova, Fässler (bib24) 2008; 14
Robert, Bertolla, Masereel, Dogné, Pochet (bib98) 2008; 51
Carro, Huybrechts, Duchesne (bib2) 2000; 31
Seitz, Meisel, Moll, Wittsack, Junghans, Siebler (bib27) 2004; 62
Wu, Vanhoorelbeke, Cauwenberghs (bib76) 2002; 99
Shattil, Ginsberg (bib20) 1997; 100
Del Zoppo, Mabuchi (bib49) 2003; 23
Kleinschnitz, Stoll, Bendszus (bib56) 2006; 203
Savage, Saldivar, Ruggeri (bib65) 1996; 84
Feigin, Lawes, Bennet, Anderson (bib3) 2003; 2
Camerlingo, Salvi, Belloni (bib37) 2005; 36
Adams, Effron, Torner (bib26) 2008; 39
Grosse, Braun, Varga-Szabo (bib86) 2007; 117
López, Andrews, Afshar-Kharghan, Berndt (bib62) 1998; 92
Fontayne, Vanhoorelbeke, Pareyn (bib77) 2006; 96
Del Zoppo (bib48) 1998; 51
Berndt, Shen, Dopheide, Gardiner, Andrews (bib70) 2001; 86
(bib9) 1995; 333
Maguire, Thakkinstian, Sturm (bib71) 2008; 39
Osterud, Rapaport (bib94) 1977; 74
Lopez, Mathers, Ezzati, Jamison, Murray (bib1) 2006; 367
Chamorro, Busse, Obach (bib38) 2005; 19
Ciccone, Abraha, Santilli (bib30) 2007; 38
Rodgers, Levin (bib68) 1990; 16
Abou-Chebl, Bajzer, Kreiger, Furlan, Yaday (bib29) 2005; 36
Heo, Lee, Kim, Kim (bib13) 2003; 60
Durukan, Strbian, Tatlisumak (bib43) 2008; 14
Bath, Lindenstrom, Boysen (bib35) 2001; 358
Soriano, Coxon, Wang (bib73) 1999; 30
Benatar (bib40) 2005; 98
Memezawa, Smith, Siesjö (bib44) 1992; 23
Abumiya, Fitridge, Mazur (bib59) 2000; 31
Al-Sadat, Sunbulli, Chaturvedi (bib33) 2002; 33
Bergmeier, Piffath, Goerge (bib67) 2006; 103
Clemetson, Polgar, Magnenat, Wells, Clemetson (bib80) 1999; 274
Romo, Dong, Schade (bib74) 1999; 190
Andersen, Olsen (bib31) 2007; 38
Choudhri, Hoh, Prestigiacomo (bib92) 1999; 190
Petrich, Marchese, Ruggeri (bib23) 2007; 204
Dirnagl, Iadecola, Moskowitz (bib7) 1999; 22
Furie, Furie (bib84) 2007; 5
Renné, Pozgajova, Grüner (bib88) 2005; 202
Gailani, Renné (bib55) 2007; 5
Lewington, Whitlock (bib4) 2007; 370
Bongers, de Maat, van Goor (bib72) 2006; 37
Ishikawa, Cooper, Arumugam, Zhang, Nanda, Granger (bib58) 2004; 24
Connolly, Winfree, Springer (bib45) 1996; 97
Adams (bib32) 2002; 33
Stoll, Bendszus (bib5) 2006; 37
Nieswandt, Schulte, Bergmeier (bib81) 2001; 193
(bib15) 1997; 349
Kleinschnitz, Pozgajova, Pham, Bendszus, Nieswandt, Stoll (bib57) 2007; 115
Okada, Copeland, Mori, Tung, Thomas, del Zoppo (bib75) 1994; 25
Crittenden, Bergmeier, Zhang (bib21) 2004; 10
Ware, Russell, Ruggeri (bib64) 2000; 97
(bib34) 1998; 279
Verro, Gorelick, Nguyen (bib18) 2008; 39
Kleinschnitz, Braeuninger, Pham (bib51) 2008; 39
Kannemeier, Shibamiya, Nakazawa (bib90) 2007; 104
Andrews, Berndt (bib63) 2004; 114
Bendszus, Stoll (bib97) 2006; 5
Salomon, Steinberg, Koren-Mong, Tanne, Seligsohn (bib91) 2008; 111
Jackson, Nesbitt, Kulkarni (bib78) 2003; 1
Bhatt, Topol (bib25) 2000; 284
Paciaroni, Agnelli, Micheli, Caso (bib39) 2007; 38
Hughes, Lip (bib6) 2008; 99
(bib12) March 3, 2008
Bergmeier, Schulte, Brockhoff, Bier, Zirngibl, Nieswandt (bib60) 2002; 48
Wong, Chen, Ng (bib36) 2007; 6
Adams, Adams, del Zoppo, Goldstein (bib11) 2005; 36
Frederix, Chauhan, Kisucka (bib50) 2007; 1185
Massberg, Gawaz, Grüner (bib82) 2003; 197
Goerge, Ho-Tin-Noe, Carbo (bib69) 2008; 111
Ciccone (2019111720345484300_B30) 2007; 38
Rodgers (2019111720345484300_B68) 1990; 16
Fontayne (2019111720345484300_B77) 2006; 96
Romo (2019111720345484300_B74) 1999; 190
Del Zoppo (2019111720345484300_B48) 1998; 51
Gubitz (2019111720345484300_B41) 2004; 3
International Stroke Trial Collaborative Group (2019111720345484300_B15) 1997; 349
Massberg (2019111720345484300_B61) 2005; 112
López (2019111720345484300_B62) 1998; 92
Abumiya (2019111720345484300_B59) 2000; 31
Nieswandt (2019111720345484300_B81) 2001; 193
Grosse (2019111720345484300_B86) 2007; 117
2019111720345484300_B12
Memezawa (2019111720345484300_B44) 1992; 23
Bongers (2019111720345484300_B72) 2006; 37
Wu (2019111720345484300_B76) 2002; 99
Varga-Szabo (2019111720345484300_B87) 2008; 205
Lopez (2019111720345484300_B1) 2006; 367
Heo (2019111720345484300_B13) 2003; 60
Kleinschnitz (2019111720345484300_B56) 2006; 203
Kleinschnitz (2019111720345484300_B57) 2007; 115
Shattil (2019111720345484300_B20) 1997; 100
Clemetson (2019111720345484300_B80) 1999; 274
Osterud (2019111720345484300_B94) 1977; 74
Del Zoppo (2019111720345484300_B49) 2003; 23
Grüner (2019111720345484300_B83) 2003; 102
Kannemeier (2019111720345484300_B90) 2007; 104
Hart (2019111720345484300_B42) 2005; 36
Orset (2019111720345484300_B52) 2007; 38
Carro (2019111720345484300_B2) 2000; 31
Adams (2019111720345484300_B16) 2007; 38
CAPRIE Steering Committee (2019111720345484300_B17) 1996; 348
Bath (2019111720345484300_B35) 2001; 358
Eckert (2019111720345484300_B28) 2005; 36
Feske (2019111720345484300_B85) 2007; 7
Bhatt (2019111720345484300_B25) 2000; 284
Kleinschnitz (2019111720345484300_B51) 2008; 39
Mackman (2019111720345484300_B89) 2004; 24
Bergmeier (2019111720345484300_B60) 2002; 48
Paciaroni (2019111720345484300_B39) 2007; 38
Soriano (2019111720345484300_B73) 1999; 30
Ishikawa (2019111720345484300_B58) 2004; 24
Mocco (2019111720345484300_B96) 2006; 105
Verro (2019111720345484300_B18) 2008; 39
The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (2019111720345484300_B9) 1995; 333
Okada (2019111720345484300_B53) 1994; 25
Nieswandt (2019111720345484300_B79) 2003; 102
on behalf of the guideline development group for the NICE national clinical guideline for management of atrial fibrillation in primary and secondary care (2019111720345484300_B6) 2008; 99
Bergmeier (2019111720345484300_B67) 2006; 103
Chamorro (2019111720345484300_B38) 2005; 19
Feigin (2019111720345484300_B3) 2003; 2
Savage (2019111720345484300_B65) 1996; 84
Bendszus (2019111720345484300_B97) 2006; 5
Maguire (2019111720345484300_B71) 2008; 39
Andrews (2019111720345484300_B63) 2004; 114
Andersen (2019111720345484300_B31) 2007; 38
Goerge (2019111720345484300_B69) 2008; 111
Choudhri (2019111720345484300_B92) 1999; 190
Coleman (2019111720345484300_B95) 2006; 203
Salomon (2019111720345484300_B91) 2008; 111
Durukan (2019111720345484300_B43) 2008; 14
Choi (2019111720345484300_B10) 2006; 37
Massberg (2019111720345484300_B66) 2003; 197
Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment Investigators (TOAST) (2019111720345484300_B34) 1998; 279
O'Collins (2019111720345484300_B8) 2006; 59
Robert (2019111720345484300_B98) 2008; 51
Furie (2019111720345484300_B84) 2007; 5
Petrich (2019111720345484300_B23) 2007; 204
Stoll (2019111720345484300_B5) 2006; 37
Dirnagl (2019111720345484300_B7) 1999; 22
Seitz (2019111720345484300_B27) 2004; 62
Wong (2019111720345484300_B36) 2007; 6
Sandercock (2019111720345484300_B19) 2008; 2
Berndt (2019111720345484300_B70) 2001; 86
Ware (2019111720345484300_B64) 2000; 97
Renné (2019111720345484300_B88) 2005; 202
Choudhri (2019111720345484300_B46) 1998; 102
Al-Sadat (2019111720345484300_B33) 2002; 33
Crittenden (2019111720345484300_B21) 2004; 10
Moser (2019111720345484300_B24) 2008; 14
Salomon (2019111720345484300_B93) 2006; 12
Jackson (2019111720345484300_B78) 2003; 1
Abou-Chebl (2019111720345484300_B29) 2005; 36
Frederix (2019111720345484300_B50) 2007; 1185
Massberg (2019111720345484300_B82) 2003; 197
Prospective Studies Collaboration (2019111720345484300_B4) 2007; 370
Okada (2019111720345484300_B75) 1994; 25
Sachs (2019111720345484300_B54) 2007; 100
Zhang (2019111720345484300_B47) 2001; 912
CAST (Chinese Acute Stroke Trial) Collaborative group (2019111720345484300_B14) 1997; 349
Connolly (2019111720345484300_B45) 1996; 97
Adams (2019111720345484300_B32) 2002; 33
Nieswandt (2019111720345484300_B22) 2007; 204
Adams (2019111720345484300_B26) 2008; 39
Camerlingo (2019111720345484300_B37) 2005; 36
Adams (2019111720345484300_B11) 2005; 36
Benatar (2019111720345484300_B40) 2005; 98
Gailani (2019111720345484300_B55) 2007; 5
References_xml – volume: 99
  start-page: 3623
  year: 2002
  end-page: 3628
  ident: bib76
  article-title: Inhibition of the von Willebrand (vWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons
  publication-title: Blood
  contributor:
    fullname: Cauwenberghs
– volume: 19
  start-page: 402
  year: 2005
  end-page: 440
  ident: bib38
  article-title: The rapid anticoagulation prevents ischemic damage study in acute stroke: final results from the writing commitee
  publication-title: Cerebrovasc Dis
  contributor:
    fullname: Obach
– volume: 98
  start-page: 147
  year: 2005
  end-page: 152
  ident: bib40
  article-title: Heparin use in acute ischaemic stroke: does evidence change practice?
  publication-title: Q J Med
  contributor:
    fullname: Benatar
– volume: 3
  start-page: 1
  year: 2004
  end-page: 49
  ident: bib41
  article-title: Anticoagulants for acute ischaemic stroke
  publication-title: Cochrane Database Syst Rev
  contributor:
    fullname: Counsell
– volume: 197
  start-page: 41
  year: 2003
  end-page: 49
  ident: bib66
  article-title: A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo
  publication-title: J Exp Med
  contributor:
    fullname: Grüner
– volume: 23
  start-page: 879
  year: 2003
  end-page: 894
  ident: bib49
  article-title: Cerebral microvessel responses to focal ischemia
  publication-title: J Cereb Blood Flow Metab
  contributor:
    fullname: Mabuchi
– volume: 60
  start-page: 1684
  year: 2003
  end-page: 1687
  ident: bib13
  article-title: Immediate reocclusion following a successful thrombolysis in acute stroke: a pilot study
  publication-title: Neurology
  contributor:
    fullname: Kim
– volume: 38
  start-page: 1655
  year: 2007
  end-page: 1711
  ident: bib16
  article-title: Guidelines for the early management of adults with ischemic stroke
  publication-title: Stroke
  contributor:
    fullname: Alberts
– volume: 24
  start-page: 907
  year: 2004
  end-page: 914
  ident: bib58
  article-title: Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion
  publication-title: J Cereb Blood Flow Metab
  contributor:
    fullname: Granger
– volume: 12
  start-page: 490
  year: 2006
  end-page: 493
  ident: bib93
  article-title: Variable bleeding manifestations characterize different types of surgery in patients with severe factor XI deficiency enabling parsimonious use of replacement therapy
  publication-title: Haemophilia
  contributor:
    fullname: Seligsohn
– volume: 36
  start-page: 1160
  year: 2005
  end-page: 1165
  ident: bib28
  article-title: Aggressive therapy with intravenous abciximab and intra-arterial rtPA and additional PTA/stenting improves clinical outcome in acute vertebrobasilar occlusion: combined local fibrinolysis and intravenous abciximab in acute vertebrobasilar stroke treatment (FAST): results of a multicenter study
  publication-title: Stroke
  contributor:
    fullname: Thomalla
– volume: 97
  start-page: 2803
  year: 2000
  end-page: 2808
  ident: bib64
  article-title: Generation and rescue of a murine model of platelet dysfunction: the Bernhard-Soulier syndrome
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Ruggeri
– volume: 102
  start-page: 1301
  year: 1998
  end-page: 1310
  ident: bib46
  article-title: Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation
  publication-title: J Clin Invest
  contributor:
    fullname: Zerwes
– volume: 358
  start-page: 702
  year: 2001
  end-page: 710
  ident: bib35
  article-title: Tinzaparin in acute ischemic stroke (TAIST): a randomized aspirin-controlled trial
  publication-title: Lancet
  contributor:
    fullname: Boysen
– volume: 367
  start-page: 1747
  year: 2006
  end-page: 1757
  ident: bib1
  article-title: Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
  publication-title: Lancet
  contributor:
    fullname: Murray
– volume: 16
  start-page: 1
  year: 1990
  end-page: 20
  ident: bib68
  article-title: A critical reappraisal of the bleeding time
  publication-title: Semin Thromb Hemost
  contributor:
    fullname: Levin
– volume: 284
  start-page: 1549
  year: 2000
  end-page: 1558
  ident: bib25
  article-title: Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes
  publication-title: JAMA
  contributor:
    fullname: Topol
– volume: 36
  start-page: 2286
  year: 2005
  end-page: 2288
  ident: bib29
  article-title: Multimodal therapy for the treatment of severe ischemic stroke combining GPIIb/IIIa antagonists and angioplasty after failure of thrombolysis
  publication-title: Stroke
  contributor:
    fullname: Yaday
– volume: 86
  start-page: 178
  year: 2001
  end-page: 188
  ident: bib70
  article-title: The vascular biology of the glycoprotein Ib-IX-V complex
  publication-title: Thromb Hemost
  contributor:
    fullname: Andrews
– volume: 74
  start-page: 5260
  year: 1977
  end-page: 5264
  ident: bib94
  article-title: Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Rapaport
– volume: 37
  start-page: 1923
  year: 2006
  end-page: 1932
  ident: bib5
  article-title: Inflammation and atherosclerosis: novel insights into plaque formation and destabilization
  publication-title: Stroke
  contributor:
    fullname: Bendszus
– volume: 6
  start-page: 407
  year: 2007
  end-page: 413
  ident: bib36
  article-title: Low-molecular-weight heparin compared with aspirin for the treatment of acute ischemic stroke in Asian patients with large occlusive disease: a randomised study
  publication-title: Lancet Neurol
  contributor:
    fullname: Ng
– volume: 102
  start-page: 4021
  year: 2003
  end-page: 4027
  ident: bib83
  article-title: Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo
  publication-title: Blood
  contributor:
    fullname: Schulte
– volume: 104
  start-page: 6388
  year: 2007
  end-page: 6393
  ident: bib90
  article-title: Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Nakazawa
– volume: 279
  start-page: 1265
  year: 1998
  end-page: 1272
  ident: bib34
  article-title: Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial
  publication-title: JAMA
– volume: 5
  start-page: 12
  year: 2007
  end-page: 17
  ident: bib84
  article-title: In vivo thrombus formation
  publication-title: J Thromb Hemost
  contributor:
    fullname: Furie
– volume: 59
  start-page: 467
  year: 2006
  end-page: 477
  ident: bib8
  article-title: 1,026 experimental treatments in acute stroke
  publication-title: Ann Neurol
  contributor:
    fullname: Howells
– volume: 193
  start-page: 459
  year: 2001
  end-page: 469
  ident: bib81
  article-title: Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice
  publication-title: J Exp Med
  contributor:
    fullname: Bergmeier
– volume: 39
  start-page: 1358
  year: 2008
  end-page: 1363
  ident: bib18
  article-title: Aspirin plus dipyridamole versus aspirin for prevention of vascular events after stroke or TIA: a meta-analysis
  publication-title: Stroke
  contributor:
    fullname: Nguyen
– volume: 912
  start-page: 181
  year: 2001
  end-page: 194
  ident: bib47
  article-title: Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion
  publication-title: Brain Res
  contributor:
    fullname: Tsang
– volume: 24
  start-page: 1015
  year: 2004
  end-page: 1022
  ident: bib89
  article-title: Role of tissue factor in hemostasis, thrombosis, and vascular development
  publication-title: Arterioscler Thromb Vasc Biol
  contributor:
    fullname: Mackman
– volume: 23
  start-page: 552
  year: 1992
  end-page: 559
  ident: bib44
  article-title: Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats
  publication-title: Stroke
  contributor:
    fullname: Siesjö
– volume: 349
  start-page: 1641
  year: 1997
  end-page: 1649
  ident: bib14
  article-title: CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischemic stroke
  publication-title: Lancet
– volume: 99
  start-page: 295
  year: 2008
  end-page: 304
  ident: bib6
  article-title: Stroke and thrombembolism in atrial fibrillation: a systemic review of stroke risk factors, risk stratification schema and cost effectiveness data
  publication-title: Thromb Haemost
  contributor:
    fullname: Lip
– volume: 36
  start-page: 1588
  year: 2005
  end-page: 1593
  ident: bib42
  article-title: Avoiding central nervous system bleeding during antithrombotic therapy
  publication-title: Stroke
  contributor:
    fullname: Pearce
– volume: 51
  start-page: 3077
  year: 2008
  end-page: 3080
  ident: bib98
  article-title: Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors
  publication-title: J Med Chem
  contributor:
    fullname: Pochet
– volume: 190
  start-page: 91
  year: 1999
  end-page: 99
  ident: bib92
  article-title: Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage
  publication-title: J Exp Med
  contributor:
    fullname: Prestigiacomo
– volume: 14
  start-page: 325
  year: 2008
  end-page: 330
  ident: bib24
  article-title: Kindlin-3 is essential for integrin activation and platelet aggregation
  publication-title: Nat Med
  contributor:
    fullname: Fässler
– volume: 14
  start-page: 359
  year: 2008
  end-page: 370
  ident: bib43
  article-title: Rodent models of ischemic stroke: a useful tool for stroke drug development
  publication-title: Curr Pharmaceutical Design
  contributor:
    fullname: Tatlisumak
– volume: 370
  start-page: 1829
  year: 2007
  end-page: 1839
  ident: bib4
  article-title: Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths
  publication-title: Lancet
  contributor:
    fullname: Whitlock
– volume: 97
  start-page: 209
  year: 1996
  end-page: 216
  ident: bib45
  article-title: Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion: role of neutrophil adhesion in the pathogenesis of stroke
  publication-title: J Clin Invest
  contributor:
    fullname: Springer
– volume: 202
  start-page: 271
  year: 2005
  end-page: 281
  ident: bib88
  article-title: Defective thrombus formation in mice lacking coagulation factor XII
  publication-title: J Exp Med
  contributor:
    fullname: Grüner
– volume: 203
  start-page: 493
  year: 2006
  end-page: 495
  ident: bib95
  article-title: Are hemoastasis and thrombosis two sides of the same coin
  publication-title: J Exp Med
  contributor:
    fullname: Coleman
– volume: 1185
  start-page: 239
  year: 2007
  end-page: 245
  ident: bib50
  article-title: Platelet adhesion receptors do not modulate infarct volume after photochemically induced stroke in mice
  publication-title: Brain Res
  contributor:
    fullname: Kisucka
– volume: 117
  start-page: 3540
  year: 2007
  end-page: 3550
  ident: bib86
  article-title: An EF hand mutation in STIM 1 causes premature platelet activation and bleeding in Mice
  publication-title: J Clin Invest
  contributor:
    fullname: Varga-Szabo
– volume: 333
  start-page: 1581
  year: 1995
  end-page: 1588
  ident: bib9
  article-title: Tissue plasminogen activator for acute ischemic stroke
  publication-title: N Engl J Med
– volume: 31
  start-page: 1402
  year: 2000
  end-page: 1410
  ident: bib59
  article-title: Integrin alphaIIbbeta3 inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia
  publication-title: Stroke
  contributor:
    fullname: Mazur
– volume: 33
  start-page: 856
  year: 2002
  end-page: 861
  ident: bib32
  article-title: Emergent use of anticoagulation for treatment of patients with ischemic stroke
  publication-title: Stroke
  contributor:
    fullname: Adams
– volume: 1
  start-page: 1602
  year: 2003
  end-page: 1612
  ident: bib78
  article-title: Signaling events underlying thrombus formation
  publication-title: J Thromb Haemost
  contributor:
    fullname: Kulkarni
– volume: 204
  start-page: 3113
  year: 2007
  end-page: 3118
  ident: bib22
  article-title: Loss of talin in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo
  publication-title: J Exp Med
  contributor:
    fullname: Pleines
– volume: 7
  start-page: 690
  year: 2007
  end-page: 702
  ident: bib85
  article-title: Calcium signalling in lymphocyte activation and disease
  publication-title: Nat Rev Immunol
  contributor:
    fullname: Feske
– volume: 48
  start-page: 80
  year: 2002
  end-page: 86
  ident: bib60
  article-title: Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody
  publication-title: Cytometry
  contributor:
    fullname: Nieswandt
– volume: 39
  start-page: 1262
  year: 2008
  end-page: 1268
  ident: bib51
  article-title: Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis
  publication-title: Stroke
  contributor:
    fullname: Pham
– volume: 111
  start-page: 4958
  year: 2008
  end-page: 4964
  ident: bib69
  article-title: Inflammation induces hemorrhage in thrombocytopenia
  publication-title: Blood
  contributor:
    fullname: Carbo
– volume: 2
  start-page: 1
  year: 2008
  end-page: 72
  ident: bib19
  article-title: Antiplatelet therapy for acute ischaemic stroke
  publication-title: Cochrane Database Syst Rev
  contributor:
    fullname: Counsell
– volume: 274
  start-page: 29019
  year: 1999
  end-page: 29024
  ident: bib80
  article-title: The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer recepotrs
  publication-title: J Biol Chem
  contributor:
    fullname: Clemetson
– volume: 38
  start-page: 1113
  year: 2007
  end-page: 1114
  ident: bib30
  article-title: Glycoprotein IIb-IIIa inhibitors for acute ischemic stroke
  publication-title: Stroke
  contributor:
    fullname: Santilli
– volume: 112
  start-page: 1180
  year: 2005
  end-page: 1188
  ident: bib61
  article-title: Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb
  publication-title: Circulation
  contributor:
    fullname: Lorenz
– volume: 39
  start-page: 1710
  year: 2008
  end-page: 1716
  ident: bib71
  article-title: Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis
  publication-title: Stroke
  contributor:
    fullname: Sturm
– volume: 197
  start-page: 41
  year: 2003
  end-page: 49
  ident: bib82
  article-title: A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vitro
  publication-title: J Exp Med
  contributor:
    fullname: Grüner
– volume: 5
  start-page: 364
  year: 2006
  end-page: 372
  ident: bib97
  article-title: Silent cerebral ischemia: hidden fingerprints of invasive medical procedures
  publication-title: Lancet Neurol
  contributor:
    fullname: Stoll
– volume: 51
  start-page: S9
  year: 1998
  end-page: S14
  ident: bib48
  article-title: The role of platelets in ischemic stroke
  publication-title: Neurology
  contributor:
    fullname: Del Zoppo
– volume: 84
  start-page: 289
  year: 1996
  end-page: 297
  ident: bib65
  article-title: Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor
  publication-title: Cell
  contributor:
    fullname: Ruggeri
– volume: 2
  start-page: 43
  year: 2003
  end-page: 53
  ident: bib3
  article-title: Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century
  publication-title: Lancet Neurol
  contributor:
    fullname: Anderson
– volume: 33
  start-page: 1574
  year: 2002
  end-page: 1577
  ident: bib33
  article-title: Use of intravenous heparin by North American neurologists: do the data matter?
  publication-title: Stroke
  contributor:
    fullname: Chaturvedi
– volume: 92
  start-page: 2366
  year: 1998
  end-page: 2373
  ident: bib62
  article-title: Bernard-Soulier syndrome
  publication-title: Blood
  contributor:
    fullname: Berndt
– volume: 38
  start-page: 423
  year: 2007
  end-page: 430
  ident: bib39
  article-title: Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a meta-analysis of randomized controlled trials
  publication-title: Stroke
  contributor:
    fullname: Caso
– volume: 39
  start-page: 87
  year: 2008
  end-page: 99
  ident: bib26
  article-title: Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial
  publication-title: Stroke
  contributor:
    fullname: Torner
– year: March 3, 2008
  ident: bib12
  publication-title: Desmoteplase in Acute Ischemic Stroke-2.
– volume: 349
  start-page: 1569
  year: 1997
  end-page: 1581
  ident: bib15
  article-title: The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischemic stroke
  publication-title: Lancet
– volume: 348
  start-page: 1329
  year: 1996
  end-page: 1339
  ident: bib17
  article-title: A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk for ischemic events (CAPRIE)
  publication-title: Lancet
– volume: 37
  start-page: 2672
  year: 2006
  end-page: 2677
  ident: bib72
  article-title: High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability
  publication-title: Stroke
  contributor:
    fullname: van Goor
– volume: 30
  start-page: 134
  year: 1999
  end-page: 139
  ident: bib73
  article-title: Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury
  publication-title: Stroke
  contributor:
    fullname: Wang
– volume: 96
  start-page: 671
  year: 2006
  end-page: 684
  ident: bib77
  article-title: Rational humanization of the powerful antithrombotic anti-GPIbalpha antibody 6B4
  publication-title: Thromb Haemost
  contributor:
    fullname: Pareyn
– volume: 10
  start-page: 982
  year: 2004
  end-page: 986
  ident: bib21
  article-title: CalDAG-GEFI integrates signalling for platelet aggregation and thrombus formation
  publication-title: Nat Med
  contributor:
    fullname: Zhang
– volume: 38
  start-page: 259
  year: 2007
  end-page: 263
  ident: bib31
  article-title: Reduced poststroke mortality in patients with stroke and atrial fibrillation treated with anticoagulants: results from a dutch quality-control registry of 22179 patients with ischemic stroke
  publication-title: Stroke
  contributor:
    fullname: Olsen
– volume: 25
  start-page: 1847
  year: 1994
  end-page: 1853
  ident: bib53
  article-title: Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion
  publication-title: Stroke
  contributor:
    fullname: del Zoppo
– volume: 37
  start-page: 419
  year: 2006
  end-page: 424
  ident: bib10
  article-title: Endovascular recanalization therapy in acute ischemic stroke
  publication-title: Stroke
  contributor:
    fullname: Mangla
– volume: 36
  start-page: 916
  year: 2005
  end-page: 921
  ident: bib11
  article-title: Guidelines for the early management of patients with ischemic stroke
  publication-title: Stroke
  contributor:
    fullname: Goldstein
– volume: 190
  start-page: 803
  year: 1999
  end-page: 814
  ident: bib74
  article-title: The glycoprotein Ib-IX-V complex is a platelet counterreceptor for p-selectin
  publication-title: J Exp Med
  contributor:
    fullname: Schade
– volume: 31
  start-page: 582
  year: 2000
  end-page: 590
  ident: bib2
  article-title: Management patterns and costs of acute ischemic stroke: an international study
  publication-title: Stroke
  contributor:
    fullname: Duchesne
– volume: 38
  start-page: 2771
  year: 2007
  end-page: 2778
  ident: bib52
  article-title: Mouse model of in situ thromboembolic stroke and reperfusion
  publication-title: Stroke
  contributor:
    fullname: Young
– volume: 103
  start-page: 16900
  year: 2006
  end-page: 16905
  ident: bib67
  article-title: The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis
  publication-title: Proc Natl Acad Sci U S A
  contributor:
    fullname: Goerge
– volume: 36
  start-page: 2415
  year: 2005
  end-page: 2420
  ident: bib37
  article-title: Intravenous heparin started within the first 3 hours after onset of symptoms as a treatment for acute nonlacunar hemispheric cerebral infarctions
  publication-title: Stroke
  contributor:
    fullname: Belloni
– volume: 205
  start-page: 1583
  year: 2008
  end-page: 1591
  ident: bib87
  article-title: The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
  publication-title: J Exp Med
  contributor:
    fullname: Kleinschnitz
– volume: 204
  start-page: 3103
  year: 2007
  end-page: 3111
  ident: bib23
  article-title: Talin is required for integrin-mediated platelet function in hemostasis and thrombosis
  publication-title: J Exp Med
  contributor:
    fullname: Ruggeri
– volume: 203
  start-page: 513
  year: 2006
  end-page: 518
  ident: bib56
  article-title: Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
  publication-title: J Exp Med
  contributor:
    fullname: Bendszus
– volume: 100
  start-page: 1
  year: 1997
  end-page: 5
  ident: bib20
  article-title: Integrin signalling in vascular biology
  publication-title: J Clin Invest
  contributor:
    fullname: Ginsberg
– volume: 100
  start-page: 979
  year: 2007
  end-page: 991
  ident: bib54
  article-title: In vivo thrombus formation in murine models
  publication-title: Circ Res
  contributor:
    fullname: Nieswandt
– volume: 114
  start-page: 447
  year: 2004
  end-page: 453
  ident: bib63
  article-title: Platelet physiology and thrombosis
  publication-title: Thromb Res
  contributor:
    fullname: Berndt
– volume: 22
  start-page: 391
  year: 1999
  end-page: 397
  ident: bib7
  article-title: Pathobiology of ischaemic stroke:an integrated view
  publication-title: Trends Neurosci
  contributor:
    fullname: Moskowitz
– volume: 5
  start-page: 733
  year: 2007
  end-page: 741
  ident: bib55
  article-title: The intrinsic pathway of coagulation: a target for treating thromboembolic disease?
  publication-title: J Thromb Hemost
  contributor:
    fullname: Renné
– volume: 111
  start-page: 4113
  year: 2008
  end-page: 4117
  ident: bib91
  article-title: Reduced incidence of ischemic stroke in patients with severe factor XI deficiency
  publication-title: Blood
  contributor:
    fullname: Seligsohn
– volume: 25
  start-page: 202
  year: 1994
  end-page: 211
  ident: bib75
  article-title: P-selectin and intercellular adhesion molecule-1 expression after focal cerebral brain ischemia and reperfusion
  publication-title: Stroke
  contributor:
    fullname: del Zoppo
– volume: 102
  start-page: 449
  year: 2003
  end-page: 461
  ident: bib79
  article-title: Platelet-collagen interaction: is GPVI the central receptor?
  publication-title: Blood
  contributor:
    fullname: Watson
– volume: 105
  start-page: 595
  year: 2006
  end-page: 601
  ident: bib96
  article-title: Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke
  publication-title: J Neurosurg
  contributor:
    fullname: Ducruet
– volume: 115
  start-page: 2323
  year: 2007
  end-page: 2330
  ident: bib57
  article-title: Targeting platlets in acute experimental stroke: impact of glycoprotein Ib, VI, IIb/IIa blockade on infarct size, functional outcome, and intracranial bleeding
  publication-title: Circulation
  contributor:
    fullname: Stoll
– volume: 62
  start-page: 2110
  year: 2004
  end-page: 2112
  ident: bib27
  article-title: The effect of combined thrombolysis with rtPA and tirofiban on ischemic brain lesions
  publication-title: Neurology
  contributor:
    fullname: Siebler
– volume: 274
  start-page: 29019
  year: 1999
  ident: 2019111720345484300_B80
  article-title: The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer recepotrs.
  publication-title: J Biol Chem
  doi: 10.1074/jbc.274.41.29019
  contributor:
    fullname: Clemetson
– volume: 25
  start-page: 202
  year: 1994
  ident: 2019111720345484300_B75
  article-title: P-selectin and intercellular adhesion molecule-1 expression after focal cerebral brain ischemia and reperfusion.
  publication-title: Stroke
  doi: 10.1161/01.STR.25.1.202
  contributor:
    fullname: Okada
– volume: 1
  start-page: 1602
  year: 2003
  ident: 2019111720345484300_B78
  article-title: Signaling events underlying thrombus formation.
  publication-title: J Thromb Haemost
  doi: 10.1046/j.1538-7836.2003.00267.x
  contributor:
    fullname: Jackson
– volume: 92
  start-page: 2366
  year: 1998
  ident: 2019111720345484300_B62
  article-title: Bernard-Soulier syndrome.
  publication-title: Blood
  contributor:
    fullname: López
– volume: 5
  start-page: 364
  year: 2006
  ident: 2019111720345484300_B97
  article-title: Silent cerebral ischemia: hidden fingerprints of invasive medical procedures.
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(06)70412-4
  contributor:
    fullname: Bendszus
– volume: 5
  start-page: 733
  year: 2007
  ident: 2019111720345484300_B55
  article-title: The intrinsic pathway of coagulation: a target for treating thromboembolic disease?
  publication-title: J Thromb Hemost
  doi: 10.1111/j.1538-7836.2007.02446.x
  contributor:
    fullname: Gailani
– volume: 193
  start-page: 459
  year: 2001
  ident: 2019111720345484300_B81
  article-title: Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice.
  publication-title: J Exp Med
  doi: 10.1084/jem.193.4.459
  contributor:
    fullname: Nieswandt
– volume: 24
  start-page: 907
  year: 2004
  ident: 2019111720345484300_B58
  article-title: Platelet-leukocyte-endothelial cell interactions after middle cerebral artery occlusion and reperfusion.
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1097/01.WCB.0000132690.96836.7F
  contributor:
    fullname: Ishikawa
– volume: 31
  start-page: 1402
  year: 2000
  ident: 2019111720345484300_B59
  article-title: Integrin alphaIIbbeta3 inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia.
  publication-title: Stroke
  doi: 10.1161/01.STR.31.6.1402
  contributor:
    fullname: Abumiya
– volume: 39
  start-page: 1262
  year: 2008
  ident: 2019111720345484300_B51
  article-title: Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis.
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.496448
  contributor:
    fullname: Kleinschnitz
– volume: 205
  start-page: 1583
  year: 2008
  ident: 2019111720345484300_B87
  article-title: The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction.
  publication-title: J Exp Med
  doi: 10.1084/jem.20080302
  contributor:
    fullname: Varga-Szabo
– volume: 333
  start-page: 1581
  year: 1995
  ident: 2019111720345484300_B9
  article-title: Tissue plasminogen activator for acute ischemic stroke.
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199512143332401
  contributor:
    fullname: The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
– volume: 204
  start-page: 3103
  year: 2007
  ident: 2019111720345484300_B23
  article-title: Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.
  publication-title: J Exp Med
  doi: 10.1084/jem.20071800
  contributor:
    fullname: Petrich
– volume: 51
  start-page: S9
  year: 1998
  ident: 2019111720345484300_B48
  article-title: The role of platelets in ischemic stroke.
  publication-title: Neurology
  doi: 10.1212/WNL.51.3_Suppl_3.S9
  contributor:
    fullname: Del Zoppo
– volume: 912
  start-page: 181
  year: 2001
  ident: 2019111720345484300_B47
  article-title: Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion.
  publication-title: Brain Res
  doi: 10.1016/S0006-8993(01)02735-4
  contributor:
    fullname: Zhang
– volume: 14
  start-page: 325
  year: 2008
  ident: 2019111720345484300_B24
  article-title: Kindlin-3 is essential for integrin activation and platelet aggregation.
  publication-title: Nat Med
  doi: 10.1038/nm1722
  contributor:
    fullname: Moser
– volume: 23
  start-page: 552
  year: 1992
  ident: 2019111720345484300_B44
  article-title: Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats.
  publication-title: Stroke
  doi: 10.1161/01.STR.23.4.552
  contributor:
    fullname: Memezawa
– volume: 2
  start-page: 1
  year: 2008
  ident: 2019111720345484300_B19
  article-title: Antiplatelet therapy for acute ischaemic stroke.
  publication-title: Cochrane Database Syst Rev
  contributor:
    fullname: Sandercock
– volume: 5
  start-page: 12
  year: 2007
  ident: 2019111720345484300_B84
  article-title: In vivo thrombus formation.
  publication-title: J Thromb Hemost
  doi: 10.1111/j.1538-7836.2007.02482.x
  contributor:
    fullname: Furie
– volume: 111
  start-page: 4113
  year: 2008
  ident: 2019111720345484300_B91
  article-title: Reduced incidence of ischemic stroke in patients with severe factor XI deficiency.
  publication-title: Blood
  doi: 10.1182/blood-2007-10-120139
  contributor:
    fullname: Salomon
– volume: 62
  start-page: 2110
  year: 2004
  ident: 2019111720345484300_B27
  article-title: The effect of combined thrombolysis with rtPA and tirofiban on ischemic brain lesions.
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000129480.17345.4A
  contributor:
    fullname: Seitz
– volume: 38
  start-page: 423
  year: 2007
  ident: 2019111720345484300_B39
  article-title: Efficacy and safety of anticoagulant treatment in acute cardioembolic stroke: a meta-analysis of randomized controlled trials.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000254600.92975.1f
  contributor:
    fullname: Paciaroni
– volume: 74
  start-page: 5260
  year: 1977
  ident: 2019111720345484300_B94
  article-title: Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.74.12.5260
  contributor:
    fullname: Osterud
– volume: 103
  start-page: 16900
  year: 2006
  ident: 2019111720345484300_B67
  article-title: The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0608207103
  contributor:
    fullname: Bergmeier
– volume: 99
  start-page: 295
  year: 2008
  ident: 2019111720345484300_B6
  article-title: Stroke and thrombembolism in atrial fibrillation: a systemic review of stroke risk factors, risk stratification schema and cost effectiveness data.
  publication-title: Thromb Haemost
  doi: 10.1160/TH07-08-0508
  contributor:
    fullname: on behalf of the guideline development group for the NICE national clinical guideline for management of atrial fibrillation in primary and secondary care
– volume: 37
  start-page: 1923
  year: 2006
  ident: 2019111720345484300_B5
  article-title: Inflammation and atherosclerosis: novel insights into plaque formation and destabilization.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000226901.34927.10
  contributor:
    fullname: Stoll
– volume: 3
  start-page: 1
  year: 2004
  ident: 2019111720345484300_B41
  article-title: Anticoagulants for acute ischaemic stroke.
  publication-title: Cochrane Database Syst Rev
  contributor:
    fullname: Gubitz
– volume: 105
  start-page: 595
  year: 2006
  ident: 2019111720345484300_B96
  article-title: Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke.
  publication-title: J Neurosurg
  doi: 10.3171/jns.2006.105.4.595
  contributor:
    fullname: Mocco
– volume: 114
  start-page: 447
  year: 2004
  ident: 2019111720345484300_B63
  article-title: Platelet physiology and thrombosis.
  publication-title: Thromb Res
  doi: 10.1016/j.thromres.2004.07.020
  contributor:
    fullname: Andrews
– volume: 97
  start-page: 209
  year: 1996
  ident: 2019111720345484300_B45
  article-title: Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion: role of neutrophil adhesion in the pathogenesis of stroke.
  publication-title: J Clin Invest
  doi: 10.1172/JCI118392
  contributor:
    fullname: Connolly
– volume: 1185
  start-page: 239
  year: 2007
  ident: 2019111720345484300_B50
  article-title: Platelet adhesion receptors do not modulate infarct volume after photochemically induced stroke in mice.
  publication-title: Brain Res
  doi: 10.1016/j.brainres.2007.07.103
  contributor:
    fullname: Frederix
– volume: 97
  start-page: 2803
  year: 2000
  ident: 2019111720345484300_B64
  article-title: Generation and rescue of a murine model of platelet dysfunction: the Bernhard-Soulier syndrome.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.050582097
  contributor:
    fullname: Ware
– volume: 48
  start-page: 80
  year: 2002
  ident: 2019111720345484300_B60
  article-title: Flow cytometric detection of activated mouse integrin alphaIIbbeta3 with a novel monoclonal antibody.
  publication-title: Cytometry
  doi: 10.1002/cyto.10114
  contributor:
    fullname: Bergmeier
– volume: 204
  start-page: 3113
  year: 2007
  ident: 2019111720345484300_B22
  article-title: Loss of talin in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo.
  publication-title: J Exp Med
  doi: 10.1084/jem.20071827
  contributor:
    fullname: Nieswandt
– volume: 370
  start-page: 1829
  year: 2007
  ident: 2019111720345484300_B4
  article-title: Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(07)61778-4
  contributor:
    fullname: Prospective Studies Collaboration
– volume: 51
  start-page: 3077
  year: 2008
  ident: 2019111720345484300_B98
  article-title: Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.
  publication-title: J Med Chem
  doi: 10.1021/jm8002697
  contributor:
    fullname: Robert
– volume: 39
  start-page: 1358
  year: 2008
  ident: 2019111720345484300_B18
  article-title: Aspirin plus dipyridamole versus aspirin for prevention of vascular events after stroke or TIA: a meta-analysis.
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.496281
  contributor:
    fullname: Verro
– volume: 14
  start-page: 359
  year: 2008
  ident: 2019111720345484300_B43
  article-title: Rodent models of ischemic stroke: a useful tool for stroke drug development.
  publication-title: Curr Pharmaceutical Design
  doi: 10.2174/138161208783497688
  contributor:
    fullname: Durukan
– volume: 33
  start-page: 1574
  year: 2002
  ident: 2019111720345484300_B33
  article-title: Use of intravenous heparin by North American neurologists: do the data matter?
  publication-title: Stroke
  doi: 10.1161/01.STR.0000018081.33541.E3
  contributor:
    fullname: Al-Sadat
– volume: 36
  start-page: 1160
  year: 2005
  ident: 2019111720345484300_B28
  article-title: Aggressive therapy with intravenous abciximab and intra-arterial rtPA and additional PTA/stenting improves clinical outcome in acute vertebrobasilar occlusion: combined local fibrinolysis and intravenous abciximab in acute vertebrobasilar stroke treatment (FAST): results of a multicenter study.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000165918.80812.1e
  contributor:
    fullname: Eckert
– volume: 25
  start-page: 1847
  year: 1994
  ident: 2019111720345484300_B53
  article-title: Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion.
  publication-title: Stroke
  doi: 10.1161/01.STR.25.9.1847
  contributor:
    fullname: Okada
– volume: 12
  start-page: 490
  year: 2006
  ident: 2019111720345484300_B93
  article-title: Variable bleeding manifestations characterize different types of surgery in patients with severe factor XI deficiency enabling parsimonious use of replacement therapy.
  publication-title: Haemophilia
  doi: 10.1111/j.1365-2516.2006.01304.x
  contributor:
    fullname: Salomon
– volume: 16
  start-page: 1
  year: 1990
  ident: 2019111720345484300_B68
  article-title: A critical reappraisal of the bleeding time.
  publication-title: Semin Thromb Hemost
  doi: 10.1055/s-2007-1002658
  contributor:
    fullname: Rodgers
– volume: 30
  start-page: 134
  year: 1999
  ident: 2019111720345484300_B73
  article-title: Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury.
  publication-title: Stroke
  doi: 10.1161/01.STR.30.1.134
  contributor:
    fullname: Soriano
– volume: 36
  start-page: 2415
  year: 2005
  ident: 2019111720345484300_B37
  article-title: Intravenous heparin started within the first 3 hours after onset of symptoms as a treatment for acute nonlacunar hemispheric cerebral infarctions.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000185730.50480.e7
  contributor:
    fullname: Camerlingo
– volume: 104
  start-page: 6388
  year: 2007
  ident: 2019111720345484300_B90
  article-title: Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation.
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0608647104
  contributor:
    fullname: Kannemeier
– volume: 284
  start-page: 1549
  year: 2000
  ident: 2019111720345484300_B25
  article-title: Current role of platelet glycoprotein IIb/IIIa inhibitors in acute coronary syndromes.
  publication-title: JAMA
  doi: 10.1001/jama.284.12.1549
  contributor:
    fullname: Bhatt
– volume: 100
  start-page: 1
  year: 1997
  ident: 2019111720345484300_B20
  article-title: Integrin signalling in vascular biology.
  publication-title: J Clin Invest
  doi: 10.1172/JCI119500
  contributor:
    fullname: Shattil
– volume: 349
  start-page: 1641
  year: 1997
  ident: 2019111720345484300_B14
  article-title: CAST: randomised placebo-controlled trial of early aspirin use in 20,000 patients with acute ischemic stroke.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(97)04010-5
  contributor:
    fullname: CAST (Chinese Acute Stroke Trial) Collaborative group
– volume: 38
  start-page: 259
  year: 2007
  ident: 2019111720345484300_B31
  article-title: Reduced poststroke mortality in patients with stroke and atrial fibrillation treated with anticoagulants: results from a dutch quality-control registry of 22179 patients with ischemic stroke.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000254622.52483.03
  contributor:
    fullname: Andersen
– volume: 38
  start-page: 2771
  year: 2007
  ident: 2019111720345484300_B52
  article-title: Mouse model of in situ thromboembolic stroke and reperfusion.
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.487520
  contributor:
    fullname: Orset
– volume: 19
  start-page: 402
  year: 2005
  ident: 2019111720345484300_B38
  article-title: The rapid anticoagulation prevents ischemic damage study in acute stroke: final results from the writing commitee.
  publication-title: Cerebrovasc Dis
  doi: 10.1159/000086100
  contributor:
    fullname: Chamorro
– volume: 36
  start-page: 916
  year: 2005
  ident: 2019111720345484300_B11
  article-title: Guidelines for the early management of patients with ischemic stroke.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000163257.66207.2d
  contributor:
    fullname: Adams
– volume: 348
  start-page: 1329
  year: 1996
  ident: 2019111720345484300_B17
  article-title: A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk for ischemic events (CAPRIE).
  publication-title: Lancet
  doi: 10.1016/S0140-6736(96)09457-3
  contributor:
    fullname: CAPRIE Steering Committee
– volume: 2
  start-page: 43
  year: 2003
  ident: 2019111720345484300_B3
  article-title: Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century.
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(03)00266-7
  contributor:
    fullname: Feigin
– volume: 102
  start-page: 4021
  year: 2003
  ident: 2019111720345484300_B83
  article-title: Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo.
  publication-title: Blood
  doi: 10.1182/blood-2003-05-1391
  contributor:
    fullname: Grüner
– volume: 197
  start-page: 41
  year: 2003
  ident: 2019111720345484300_B82
  article-title: A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vitro.
  publication-title: J Exp Med
  doi: 10.1084/jem.20020945
  contributor:
    fullname: Massberg
– volume: 22
  start-page: 391
  year: 1999
  ident: 2019111720345484300_B7
  article-title: Pathobiology of ischaemic stroke:an integrated view.
  publication-title: Trends Neurosci
  doi: 10.1016/S0166-2236(99)01401-0
  contributor:
    fullname: Dirnagl
– volume: 115
  start-page: 2323
  year: 2007
  ident: 2019111720345484300_B57
  article-title: Targeting platlets in acute experimental stroke: impact of glycoprotein Ib, VI, IIb/IIa blockade on infarct size, functional outcome, and intracranial bleeding.
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.107.691279
  contributor:
    fullname: Kleinschnitz
– volume: 112
  start-page: 1180
  year: 2005
  ident: 2019111720345484300_B61
  article-title: Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb.
  publication-title: Circulation
  doi: 10.1161/CIRCULATIONAHA.105.539221
  contributor:
    fullname: Massberg
– volume: 190
  start-page: 91
  year: 1999
  ident: 2019111720345484300_B92
  article-title: Targeted inhibition of intrinsic coagulation limits cerebral injury in stroke without increasing intracerebral hemorrhage.
  publication-title: J Exp Med
  doi: 10.1084/jem.190.1.91
  contributor:
    fullname: Choudhri
– volume: 36
  start-page: 1588
  year: 2005
  ident: 2019111720345484300_B42
  article-title: Avoiding central nervous system bleeding during antithrombotic therapy.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000170642.39876.f2
  contributor:
    fullname: Hart
– volume: 98
  start-page: 147
  year: 2005
  ident: 2019111720345484300_B40
  article-title: Heparin use in acute ischaemic stroke: does evidence change practice?
  publication-title: Q J Med
  doi: 10.1093/qjmed/hci014
  contributor:
    fullname: Benatar
– volume: 111
  start-page: 4958
  year: 2008
  ident: 2019111720345484300_B69
  article-title: Inflammation induces hemorrhage in thrombocytopenia.
  publication-title: Blood
  doi: 10.1182/blood-2007-11-123620
  contributor:
    fullname: Goerge
– volume: 84
  start-page: 289
  year: 1996
  ident: 2019111720345484300_B65
  article-title: Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor.
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80983-6
  contributor:
    fullname: Savage
– volume: 60
  start-page: 1684
  year: 2003
  ident: 2019111720345484300_B13
  article-title: Immediate reocclusion following a successful thrombolysis in acute stroke: a pilot study.
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000063323.23493.98
  contributor:
    fullname: Heo
– volume: 102
  start-page: 449
  year: 2003
  ident: 2019111720345484300_B79
  article-title: Platelet-collagen interaction: is GPVI the central receptor?
  publication-title: Blood
  doi: 10.1182/blood-2002-12-3882
  contributor:
    fullname: Nieswandt
– volume: 31
  start-page: 582
  year: 2000
  ident: 2019111720345484300_B2
  article-title: Management patterns and costs of acute ischemic stroke: an international study.
  publication-title: Stroke
  doi: 10.1161/01.STR.31.3.582
  contributor:
    fullname: Carro
– volume: 86
  start-page: 178
  year: 2001
  ident: 2019111720345484300_B70
  article-title: The vascular biology of the glycoprotein Ib-IX-V complex.
  publication-title: Thromb Hemost
  doi: 10.1055/s-0037-1616216
  contributor:
    fullname: Berndt
– volume: 99
  start-page: 3623
  year: 2002
  ident: 2019111720345484300_B76
  article-title: Inhibition of the von Willebrand (vWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons.
  publication-title: Blood
  doi: 10.1182/blood.V99.10.3623
  contributor:
    fullname: Wu
– volume: 24
  start-page: 1015
  year: 2004
  ident: 2019111720345484300_B89
  article-title: Role of tissue factor in hemostasis, thrombosis, and vascular development.
  publication-title: Arterioscler Thromb Vasc Biol
  doi: 10.1161/01.ATV.0000130465.23430.74
  contributor:
    fullname: Mackman
– volume: 100
  start-page: 979
  year: 2007
  ident: 2019111720345484300_B54
  article-title: In vivo thrombus formation in murine models.
  publication-title: Circ Res
  doi: 10.1161/01.RES.0000261936.85776.5f
  contributor:
    fullname: Sachs
– ident: 2019111720345484300_B12
– volume: 202
  start-page: 271
  year: 2005
  ident: 2019111720345484300_B88
  article-title: Defective thrombus formation in mice lacking coagulation factor XII.
  publication-title: J Exp Med
  doi: 10.1084/jem.20050664
  contributor:
    fullname: Renné
– volume: 7
  start-page: 690
  year: 2007
  ident: 2019111720345484300_B85
  article-title: Calcium signalling in lymphocyte activation and disease.
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri2152
  contributor:
    fullname: Feske
– volume: 203
  start-page: 513
  year: 2006
  ident: 2019111720345484300_B56
  article-title: Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis.
  publication-title: J Exp Med
  doi: 10.1084/jem.20052458
  contributor:
    fullname: Kleinschnitz
– volume: 38
  start-page: 1655
  year: 2007
  ident: 2019111720345484300_B16
  article-title: Guidelines for the early management of adults with ischemic stroke.
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.181486
  contributor:
    fullname: Adams
– volume: 39
  start-page: 87
  year: 2008
  ident: 2019111720345484300_B26
  article-title: Emergency administration of abciximab for treatment of patients with acute ischemic stroke: results of an international phase III trial.
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.106.476648
  contributor:
    fullname: Adams
– volume: 203
  start-page: 493
  year: 2006
  ident: 2019111720345484300_B95
  article-title: Are hemoastasis and thrombosis two sides of the same coin.
  publication-title: J Exp Med
  doi: 10.1084/jem.20060217
  contributor:
    fullname: Coleman
– volume: 59
  start-page: 467
  year: 2006
  ident: 2019111720345484300_B8
  article-title: 1,026 experimental treatments in acute stroke.
  publication-title: Ann Neurol
  doi: 10.1002/ana.20741
  contributor:
    fullname: O'Collins
– volume: 6
  start-page: 407
  year: 2007
  ident: 2019111720345484300_B36
  article-title: Low-molecular-weight heparin compared with aspirin for the treatment of acute ischemic stroke in Asian patients with large occlusive disease: a randomised study.
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(07)70079-0
  contributor:
    fullname: Wong
– volume: 96
  start-page: 671
  year: 2006
  ident: 2019111720345484300_B77
  article-title: Rational humanization of the powerful antithrombotic anti-GPIbalpha antibody 6B4.
  publication-title: Thromb Haemost
  doi: 10.1160/TH06-06-0297
  contributor:
    fullname: Fontayne
– volume: 102
  start-page: 1301
  year: 1998
  ident: 2019111720345484300_B46
  article-title: Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation.
  publication-title: J Clin Invest
  doi: 10.1172/JCI3338
  contributor:
    fullname: Choudhri
– volume: 117
  start-page: 3540
  year: 2007
  ident: 2019111720345484300_B86
  article-title: An EF hand mutation in STIM 1 causes premature platelet activation and bleeding in Mice.
  publication-title: J Clin Invest
  doi: 10.1172/JCI32312
  contributor:
    fullname: Grosse
– volume: 10
  start-page: 982
  year: 2004
  ident: 2019111720345484300_B21
  article-title: CalDAG-GEFI integrates signalling for platelet aggregation and thrombus formation.
  publication-title: Nat Med
  doi: 10.1038/nm1098
  contributor:
    fullname: Crittenden
– volume: 358
  start-page: 702
  year: 2001
  ident: 2019111720345484300_B35
  article-title: Tinzaparin in acute ischemic stroke (TAIST): a randomized aspirin-controlled trial.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(01)05837-8
  contributor:
    fullname: Bath
– volume: 39
  start-page: 1710
  year: 2008
  ident: 2019111720345484300_B71
  article-title: Polymorphisms in platelet glycoprotein 1balpha and factor VII and risk of ischemic stroke: a meta-analysis.
  publication-title: Stroke
  doi: 10.1161/STROKEAHA.107.507228
  contributor:
    fullname: Maguire
– volume: 23
  start-page: 879
  year: 2003
  ident: 2019111720345484300_B49
  article-title: Cerebral microvessel responses to focal ischemia.
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1097/01.WCB.0000078322.96027.78
  contributor:
    fullname: Del Zoppo
– volume: 38
  start-page: 1113
  year: 2007
  ident: 2019111720345484300_B30
  article-title: Glycoprotein IIb-IIIa inhibitors for acute ischemic stroke.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000258356.68323.6d
  contributor:
    fullname: Ciccone
– volume: 33
  start-page: 856
  year: 2002
  ident: 2019111720345484300_B32
  article-title: Emergent use of anticoagulation for treatment of patients with ischemic stroke.
  publication-title: Stroke
  doi: 10.1161/hs0302.104628
  contributor:
    fullname: Adams
– volume: 279
  start-page: 1265
  year: 1998
  ident: 2019111720345484300_B34
  article-title: Low molecular weight heparinoid, ORG 10172 (danaparoid), and outcome after acute ischemic stroke: a randomized controlled trial.
  publication-title: JAMA
  doi: 10.1001/jama.279.16.1265
  contributor:
    fullname: Publications Committee for the Trial of ORG 10172 in Acute Stroke Treatment Investigators (TOAST)
– volume: 37
  start-page: 2672
  year: 2006
  ident: 2019111720345484300_B72
  article-title: High von Willebrand factor levels increase the risk of first ischemic stroke: influence of ADAMTS13, inflammation, and genetic variability.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000244767.39962.f7
  contributor:
    fullname: Bongers
– volume: 349
  start-page: 1569
  year: 1997
  ident: 2019111720345484300_B15
  article-title: The International Stroke Trial (IST): a randomised trial of aspirin, subcutaneous heparin, both, or neither among 19435 patients with acute ischemic stroke.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(97)04011-7
  contributor:
    fullname: International Stroke Trial Collaborative Group
– volume: 190
  start-page: 803
  year: 1999
  ident: 2019111720345484300_B74
  article-title: The glycoprotein Ib-IX-V complex is a platelet counterreceptor for p-selectin.
  publication-title: J Exp Med
  doi: 10.1084/jem.190.6.803
  contributor:
    fullname: Romo
– volume: 367
  start-page: 1747
  year: 2006
  ident: 2019111720345484300_B1
  article-title: Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data.
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)68770-9
  contributor:
    fullname: Lopez
– volume: 197
  start-page: 41
  year: 2003
  ident: 2019111720345484300_B66
  article-title: A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo.
  publication-title: J Exp Med
  doi: 10.1084/jem.20020945
  contributor:
    fullname: Massberg
– volume: 36
  start-page: 2286
  year: 2005
  ident: 2019111720345484300_B29
  article-title: Multimodal therapy for the treatment of severe ischemic stroke combining GPIIb/IIIa antagonists and angioplasty after failure of thrombolysis.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000179043.73314.4f
  contributor:
    fullname: Abou-Chebl
– volume: 37
  start-page: 419
  year: 2006
  ident: 2019111720345484300_B10
  article-title: Endovascular recanalization therapy in acute ischemic stroke.
  publication-title: Stroke
  doi: 10.1161/01.STR.0000198808.90579.65
  contributor:
    fullname: Choi
SSID ssj0014325
Score 2.4293418
SecondaryResourceType review_article
Snippet In ischemic stroke, treatment options are limited. Therapeutic thrombolysis is restricted to the first few hours after stroke, and the utility of current...
SourceID proquest
crossref
pubmed
pascalfrancis
elsevier
SourceType Aggregation Database
Index Database
Publisher
StartPage 3555
SubjectTerms Animals
Anticoagulants - therapeutic use
Biological and medical sciences
Blood Coagulation
Blood Platelets - physiology
Brain Ischemia - complications
Brain Ischemia - physiopathology
Brain Ischemia - therapy
Disease Models, Animal
Hematologic and hematopoietic diseases
Humans
Intracranial Thrombosis - complications
Intracranial Thrombosis - physiopathology
Intracranial Thrombosis - therapy
Medical sciences
Neurology
Platelet Aggregation Inhibitors - therapeutic use
Platelet Membrane Glycoproteins - physiology
Stroke - etiology
Stroke - physiopathology
Stroke - prevention & control
Stroke - therapy
Thrombolytic Therapy
Vascular diseases and vascular malformations of the nervous system
Title Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment
URI https://dx.doi.org/10.1182/blood-2008-04-144758
https://www.ncbi.nlm.nih.gov/pubmed/18676880
https://search.proquest.com/docview/69702713
Volume 112
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NTbBJCEHHWPkofkC8RY0dx3H21lVMg1GeGNpb5CQXVEGTirRI_Pc7f6RoDxMSUqRYsZ2cfKe7-8V3PoB3GEvqyUWU66SJZG6olaR1JEkvyIYsZOVyYRZf1OW1_HST3uzBfMiFsWGVQfd7ne60dXgyDas5XS-XNseXzGmecWG9EJ5kD-BAkPdLwn4wO_929Xm3mSAT4QsZEHi2E0IGHXnWUx8d7mMAZMTt6Xf6Pgv1eG16WrfGF7y43yN1luniKTwJLiWbeaqfwR62IzietQSnV3_Ye-aCPN3f8xE8PB9ah_Oh1NsIHi3CDvsxfF8M9XLZCm1W8LJf9axrmK2nsCq3PdulO7IlXQSObXg9oxd1P_CMtd1v_Ek9vQX9PTNtzXywuZvIdnHtz-H64sPX-WUUijFEVRqLTYQ8rpLaNLKiu8BGSZSZrtGUBo20sEvLitBHiYTBhFEmM6XWKpV2KMc6OYH9tmvxFBivU4E6zUVlCBzSqLispOKq5KqJOZoxRAMDirU_c6NwWEWLwjEs1M6UhWfYGLKBS8Ud2SnILPxj5uQOU3efE-RIE23pGN4OXC6IJ3YzxbTYbftC5Rkhep6M4YVn_l9StSIMp-OX_03WKzhyIulSHl_D_ubXFt-Q77MpJ0G2J-T9f7y6BQWNAlo
link.rule.ids 315,783,787,27583,27938,27939,45677
linkProvider Elsevier
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swED-6lq2FMbZ0a7OPVg9jbyaWLMty39Kwkq1Jn9rRNyHbcglb7FAng_33PX04ow9lMDBYWJJ96Cd097PudACfTcyxJmdRLpM64rnGUpJWEcd1gdeoIUsXCzO_EtMb_v02vd2BSR8LY90qw9rv13S3WocnozCao9ViYWN8UZ3mGWXWCqFJ9gz20BrIkIHtjc9_XM62mwk8YT6RAZJn2yFE0KFlPfLe4d4HgEfUnn4nn9JQL1e6w3GrfcKLpy1Sp5kuXsOrYFKSsZf6DeyYZgCH4wbp9PIP-UKck6f7ez6A5-d9aX_Sp3obwIt52GE_hLt5ny-XLI2NCl50y460NbH5FJbFpiPbcEeywAvJsXWvJ_ii9qc5I0372_zCms6S_o7opiLe2dx1JFu_9rdwc_H1ejKNQjKGqExjto4Mjcuk0jUv8c5MLbjhmayMLrTR3NIuyUtkH4VBDsa00JkupBQpt02pqZJ3sNu0jTkGQquUGZnmrNRIDrFVXJRcUFFQUcfU6CFEPQBq5c_cUI6rSKYcYCF3JlcesCFkPUrq0dxRqBb-0fPkEajbzzE0pFG2dAinPcoKMbGbKbox7aZTIs-Q0dNkCEce_L-iSoEcTsbv_1usU9ifXs9navbt6vIDHLjp6cIfP8Lu-n5jPqEdtC5Owjx_ADbzBE8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+mechanisms+of+thrombus+formation+in+ischemic+stroke%3A+novel+insights+and+targets+for+treatment&rft.jtitle=Blood&rft.au=Stoll%2C+Guido&rft.au=Kleinschnitz%2C+Christoph&rft.au=Nieswandt%2C+Bernhard&rft.date=2008-11-01&rft.issn=0006-4971&rft.eissn=1528-0020&rft.volume=112&rft.issue=9&rft.spage=3555&rft.epage=3562&rft_id=info:doi/10.1182%2Fblood-2008-04-144758&rft.externalDBID=n%2Fa&rft.externalDocID=10_1182_blood_2008_04_144758
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-4971&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-4971&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-4971&client=summon