Structure-Based Design, Synthesis, and Biological Evaluation of the Cage–Amide Derived Orthopox Virus Replication Inhibitors

• Published in: Viruses Vol. 15; no. 1; p. 29
• Main Authors: Mozhaitsev, Evgenii S., Suslov, Evgeniy V., Rastrepaeva, Daria A., Yarovaya, Olga I., Borisevich, Sophia S., Khamitov, Edward M., Kolybalov, Dmitry S., Arkhipov, Sergey G., Bormotov, Nikolai I., Shishkina, Larisa N., Serova, Olga A., Brunilin, Roman V., Vernigora, Andrey A., Nawrozkij, Maxim B., Agafonov, Alexander P., Maksyutov, Rinat A., Volcho, Konstantin P., Salakhutdinov, Nariman F.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.12.2022; MDPI
• Subjects: adamantane; Amides; Amides - pharmacology; Animals; antipox activity; Benzoic acid; Binding sites; Biological activity; biological assessment; Cell culture; Communicable Diseases; Coronaviruses; COVID-19; Cowpox; energy; Epidemics; Investigations; Mice; Mpox; Orthopoxvirus; p37; Proteins; Smallpox; Vaccinia virus; Variola virus; Virus Replication; Viruses; United States > US; adamantane; amides; antipox activity; p37

Despite the fact that the variola virus is considered eradicated, the search for new small molecules with activity against orthopoxviruses remains an important task, especially in the context of recent outbreaks of monkeypox. As a result of this work, a number of amides of benzoic acids containing a...