Identification of miR-26 as a key mediator of estrogen stimulated cell proliferation by targeting CHD1, GREB1 and KPNA2

• Published in: Breast cancer research : BCR Vol. 16; no. 2; p. R40
• Main Authors: Tan, Sheng, Ding, Keshuo, Li, Rui, Zhang, Weijie, Li, Gaopeng, Kong, Xiangjun, Qian, Pengxu, Lobie, Peter E, Zhu, Tao
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 15.04.2014; BioMed Central
• Subjects: alpha Karyopherins - genetics; alpha Karyopherins - metabolism; Animals; Blotting, Western; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cell Line, Tumor; Cell Proliferation - drug effects; DNA Helicases - genetics; DNA Helicases - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Estradiol - pharmacology; Estrogens - pharmacology; Gene Expression Regulation, Neoplastic - drug effects; Humans; MCF-7 Cells; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - genetics; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Proto-Oncogene Proteins c-myc - genetics; Proto-Oncogene Proteins c-myc - metabolism; Receptors, Estrogen - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Xenograft Model Antitumor Assays

Estrogen signaling is pivotal in the progression of estrogen receptor positive breast cancer primarily by the regulation of cell survival and proliferation. Micro (mi)RNAs have been demonstrated to be regulated by estrogen to mediate estrogenic effects. Herein, we determined the role of estrogen reg...