The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 27; no. 5; pp. 1016 - 1030
• Main Authors: Capuano, Alessandra, Vescovo, Maddalena, Canesi, Simone, Pivetta, Eliana, Doliana, Roberto, Nadin, Maria Grazia, Yamamoto, Masami, Tsukamoto, Tetsuya, Nomura, Sachiyo, Pilozzi, Emanuela, Palumbo, Antonio, Canzonieri, Vincenzo, Cannizzaro, Renato, Scanziani, Eugenio, Baldassarre, Gustavo, Mongiat, Maurizio, Spessotto, Paola
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.09.2024; Springer Nature B.V
• Subjects: Abdominal Surgery; Animal models; Animals; Biopsy; Cancer Research; Cancer therapies; Carcinogenesis; Cell culture; Colon cancer; Colorectal cancer; Disease Progression; Elastin microfibril interface located protein; Extracellular matrix; Gastric cancer; Gastroenterology; Humans; Lymphangiogenesis; Matrix protein; Medicine; Medicine & Public Health; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; Methylnitrosourea; Mice; Mice, Transgenic; Mutation; N-Methyl-N-nitrosourea; Oncology; Original; Original Article; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Surgical Oncology; Transgenic animals; Transgenic mice; Tumor Microenvironment; Tumorigenesis; Tumors; Extracellular matrix; Tumor microenvironment; Lymphatic vessels; Gastrointestinal intraepithelial neoplasia; Mouse models

Background The contribution of the tumor microenvironment and extracellular matrix to the aggressive biology of Gastric Cancer (GC) has been recently characterized; however, the role of EMILIN-1 in this context is unknown. EMILIN-1 is an essential structural element for the maintenance of lymphatic...