ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No sign...

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Published inBiomarkers Vol. 20; no. 3; pp. 196 - 201
Main Authors Manzine, Patricia Regina, Marcello, Elena, Borroni, Barbara, Kamphuis, Willem, Hol, Elly, Padovani, Alessandro, Nascimento, Carla Crispim, de Godoy Bueno, Patricia, Assis Carvalho Vale, Francisco, Iost Pavarini, Sofia Cristina, Di Luca, Monica, Cominetti, Márcia Regina
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 03.04.2015
Subjects
ADAM Proteins - blood
ADAM Proteins - genetics
ADAM10 Protein
Aged
Aged, 80 and over
Aging
Alzheimer Disease - blood
Alzheimer Disease - genetics
Alzheimer Disease - physiopathology
Amyloid Precursor Protein Secretases - blood
Amyloid Precursor Protein Secretases - genetics
biomarkers
Biomarkers - blood
blood
Blood Platelets - metabolism
Blood Platelets - pathology
Case-Control Studies
Cognitive Dysfunction - blood
Cognitive Dysfunction - genetics
Cognitive Dysfunction - physiopathology
Female
Gene Expression
Humans
Male
Membrane Proteins - blood
Membrane Proteins - genetics
Middle Aged
Neuropsychological Tests
platelets
RNA, Messenger - blood
RNA, Messenger - genetics
Aging
blood
biomarkers
platelets
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Abstract ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.
AbstractList ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein.
Author Manzine, Patricia Regina
Assis Carvalho Vale, Francisco
Borroni, Barbara
Kamphuis, Willem
Hol, Elly
Marcello, Elena
Iost Pavarini, Sofia Cristina
Di Luca, Monica
Cominetti, Márcia Regina
Padovani, Alessandro
de Godoy Bueno, Patricia
Nascimento, Carla Crispim
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  organization: Department of Gerontology, Federal University of São Carlos
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  givenname: Elena
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  fullname: Marcello, Elena
  organization: Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano
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  organization: Department of Clinical and Experimental Science, Neurology Unit, University of Brescia
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  organization: Department of Medicine, Federal University of São Carlos
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  organization: Department of Gerontology, Federal University of São Carlos
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Snippet ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total...
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SubjectTerms ADAM Proteins - blood
ADAM Proteins - genetics
ADAM10 Protein
Aged
Aged, 80 and over
Aging
Alzheimer Disease - blood
Alzheimer Disease - genetics
Alzheimer Disease - physiopathology
Amyloid Precursor Protein Secretases - blood
Amyloid Precursor Protein Secretases - genetics
biomarkers
Biomarkers - blood
blood
Blood Platelets - metabolism
Blood Platelets - pathology
Case-Control Studies
Cognitive Dysfunction - blood
Cognitive Dysfunction - genetics
Cognitive Dysfunction - physiopathology
Female
Gene Expression
Humans
Male
Membrane Proteins - blood
Membrane Proteins - genetics
Middle Aged
Neuropsychological Tests
platelets
RNA, Messenger - blood
RNA, Messenger - genetics
Title ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects
URI https://www.tandfonline.com/doi/abs/10.3109/1354750X.2015.1062554
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Volume 20
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