Olive oil-induced reduction of oxidative damage and inflammation promotes wound healing of pressure ulcers in mice

• Published in: Journal of dermatological science Vol. 83; no. 1; pp. 60 - 69
• Main Authors: Donato-Trancoso, Aline, Monte-Alto-Costa, Andréa, Romana-Souza, Bruna
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ireland Ltd 01.07.2016
• Subjects: Administration, Cutaneous; Animals; Collagen - metabolism; Cutaneous wound healing; Dermatology; Disease Models, Animal; Humans; Inflammation; Inflammation - drug therapy; Male; Mice; Nitric Oxide - metabolism; Olive oil; Olive Oil - administration & dosage; Olive Oil - therapeutic use; Oxidative damage; Pressure ulcer; Pressure Ulcer - drug therapy; Re-Epithelialization - drug effects; Reactive Oxygen Species - metabolism; Skin - blood supply; Skin - drug effects; Skin - metabolism; Transforming Growth Factor beta1 - metabolism; Tumor Necrosis Factor-alpha - metabolism; Vascular Endothelial Growth Factor A - metabolism; Wound Healing - drug effects; NO; MCP-1; Oxidative damage; Pressure ulcer; IR; mRNA; Inflammation; Olive oil; VEGF-A; Cutaneous wound healing; α-SMA; TNF-α; MMP-1; ROS; TGF-β1; cDNA; qPCR; Mice; RFL-10; α-smooth muscle actin; monocyte chemoattractant protein-1; vascular endothelial growth factor-A; complementary DNA; ribosomal protein L 10; messenger RNA; reactive oxygen species; TGF-β 1; transforming growth factor-β1; matrixmetalloproteinase-1; nitric oxide; quantitative polymerase chain reaction; tumor necrosis factor-α; Ischemia-Reperfusion

[Display omitted] •Olive oil accelerated ROS and NO synthesis in mice pressure ulcers.•Olive oil decreased inflammatory response and oxidative damage in pressure ulcers.•Olive oil improved re-epithelialization loss in pressure ulcers.•Olive oil accelerated dermal reconstruction and wound closure in...