Multiscale Model of Antiviral Timing, Potency, and Heterogeneity Effects on an Epithelial Tissue Patch Infected by SARS-CoV-2 - Ferrari Gianlupi, Juliano; Mapder, Tarunendu; Sego, T. J.; Sluka, James P.; Quinney, Sara K.; Craig, Morgan; Stratford, Robert E.; Glazier, James A. (Viruses, 2022)
Keywords: agent-based model; Antiviral agents; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Antiviral drugs; antiviral therapy; bioinformatics; Cell culture; Clinical trials; Computer applications; Coronaviruses; COVID-19; COVID-19 Drug Treatment; COVID-19 infection; Disease; Drug dosages; Drug metabolism; Drug resistance; drugs; Epithelium; half life; Humans; Infections; lungs; Mathematical models; Metabolism; Metabolites; mPBPK; Pandemics; Permeability; Pharmacodynamics; Pharmacokinetics; Population; remdesivir; RNA polymerase; SARS-CoV-2; Schedules; Severe acute respiratory syndrome coronavirus 2; Simulation; Viral infections; virtual tissue simulation; Virus Replication; Viruses; virtual tissue simulation; SARS-CoV-2; agent-based model; tissue model; remdesivir; antiviral therapy; multiscale model; mPBPK