Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC–MS analysis and phytochemical investigation

• Published in: Journal of natural medicines Vol. 75; no. 4; pp. 1058 - 1066
• Main Authors: Otsuki, Kouharu, Zhang, Mi, Kikuchi, Takashi, Tsuji, Minami, Tejima, Miyuko, Bai, Zi-Song, Zhou, Di, Huang, Li, Chen, Chin-Ho, Lee, Kuo-Hsiung, Li, Ning, Koike, Kazuo, Li, Wei
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.09.2021; Springer Nature B.V
• Subjects: antiretroviral agents; antiretroviral properties; Antiviral activity; Biological products; Biomedical and Life Sciences; Biomedicine; Complementary & Alternative Medicine; Diterpenes; diterpenoids; HIV; HIV infections; Human immunodeficiency virus; Medicinal Chemistry; ortho esters; Orthoesters; Pharmacology/Toxicology; Pharmacy; Phytochemicals; Plant Sciences; Wikstroemia; Anti-HIV; Thymelaeaceae; Macrocyclic daphnane orthoester; LC–MS

Macrocyclic daphnane orthoesters (MDOs) have attracted significant research interest for the drug discovery to cure HIV infection based on the “Shock and Kill” strategy. In the present study, the first chemical study on Wikstroemia ligustrina (Thymelaeaceae) was carried out by LC–MS analysis and phy...