Exosomes derived from magnetically actuated bone mesenchymal stem cells promote tendon-bone healing through the miR-21-5p/SMAD7 pathway

• Published in: Materials today bio Vol. 15; p. 100319
• Main Authors: Wu, Xiang-Dong, Kang, Lin, Tian, Jingjing, Wu, Yuanhao, Huang, Yue, Liu, Jieying, Wang, Hai, Qiu, Guixing, Wu, Zhihong
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.06.2022; Elsevier
• Subjects: Anterior cruciate ligament reconstruction; Exosomes; Fibroblast; Full Length; Iron oxide nanoparticles; miR-21-5p; Tendon-to-bone healing; Anterior cruciate ligament reconstruction; Tendon-to-bone healing; Iron oxide nanoparticles; Exosomes; Fibroblast; miR-21-5p

Graft healing after anterior cruciate ligament reconstruction (ACLR) involves slow biological processes, and various types of biological modulations have been explored to promote tendon-to-bone integration. Exosomes have been extensively studied as a promising new cell-free strategy for tissue regen...