Activation in M1 but not M2 Macrophages Contributes to Cardiac Remodeling after Myocardial Infarction in Rats: a Critical Role of the Calcium Sensing Receptor/NRLP3 Inflammasome

• Published in: Cellular physiology and biochemistry Vol. 35; no. 6; pp. 2483 - 2500
• Main Authors: Liu, Wenxiu, Zhang, Xin, Zhao, Meng, Zhang, Xiaohui, Chi, Jinyu, Liu, Yue, Lin, Fang, Fu, Yu, Ma, Dandan, Yin, Xinhua
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Cell Physiol Biochem Press GmbH & Co KG 01.01.2015
• Subjects: Actins - metabolism; Animals; Calcium sensing receptor; Cardiac remodeling; Carrier Proteins - metabolism; Collagen - metabolism; Down-Regulation - physiology; Extracellular Matrix - metabolism; Fibroblasts - metabolism; Fibrosis - metabolism; Fibrosis - physiopathology; Heart - physiopathology; Heart Ventricles - metabolism; Heart Ventricles - physiopathology; Inflammasomes - metabolism; Interleukin-1beta - metabolism; Macrophage; Macrophages - metabolism; Macrophages - physiology; Male; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - metabolism; Myocardial infarction; Myocardial Infarction - metabolism; Myocardial Infarction - physiopathology; Myocardium - metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; NLRP3 inflammasome; Original Paper; Rats; Rats, Wistar; Receptors, Calcium-Sensing - metabolism; Signal Transduction - physiology; Tissue Inhibitor of Metalloproteinase-2 - metabolism; Up-Regulation - physiology; Ventricular Remodeling - physiology; Myocardial infarction; Cardiac remodeling; NLRP3 inflammasome; Calcium sensing receptor; Macrophage

Aims: Macrophage (MΦ) infiltration during myocardial infarction (MI) amplifies cardiac inflammation and remodeling. We investigated whether activation of the NRLP3 inflammasome by a calcium sensing receptor (CaSR) in MΦ subsets contributes to cardiac remodeling following MI. Methods and Results: Inf...