Transient Increases in Inflammation and Proapoptotic Potential Are Associated with the HESN Phenotype Observed in a Subgroup of Kenyan Female Sex Workers

• Published in: Viruses Vol. 14; no. 3; p. 471
• Main Authors: Gluchowski, Marcel, Yu, Xiaoqiong, Abrenica, Bernard, Yao, Samantha, Kimani, Joshua, Douville, Renée N., Ball, Terry Blake, Su, Ruey-Chyi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.02.2022; MDPI
• Subjects: antiviral; Antiviral Agents; Antiviral drugs; Apoptosis; CD4 antigen; Female; females; Genotype & phenotype; HESN; HIV; HIV Infections; HIV-1; Human immunodeficiency virus; Humans; IFN-γ; Infections; Inflammation; Interferon regulatory factor 1; ISG; Kenya; Leukocytes, Mononuclear; Lymphocytes; Lymphocytes T; Mucosal immunity; PBMC; Peripheral blood mononuclear cells; Phenotype; Phenotypes; Regulation; Sex industry; Sex Workers; Sexual behavior; Transcription; transcription (genetics); Viral infections; γ-Interferon; Kenya; Nairobi Kenya; Canada; HIV-1; commercial sex workers; IFN-γ; antiviral; HESN; ISG; PBMC

Interferon (IFN) -stimulated genes (ISGs) are critical effectors of IFN response to viral infection, but whether ISG expression is a correlate of protection against HIV infection remains elusive. A well-characterized subcohort of Kenyan female sex workers, who, despite being repeatedly exposed to HI...