A mouse model of human repetitive mild traumatic brain injury

• Published in: Journal of neuroscience methods Vol. 203; no. 1; pp. 41 - 49
• Main Authors: Kane, Michael J., Angoa-Pérez, Mariana, Briggs, Denise I., Viano, David C., Kreipke, Christian W., Kuhn, Donald M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2012
• Subjects: Animals; Brain Injuries - metabolism; Brain Injuries - pathology; Concussive; Disease Models, Animal; Glial Fibrillary Acidic Protein; Head acceleration; Humans; Immunoblotting; Immunohistochemistry; Mice; Mild; Nerve Tissue Proteins - analysis; Nerve Tissue Proteins - metabolism; Recovery of Function; Repetitive; Tauopathy; Traumatic brain injury; Mild; Traumatic brain injury; Head acceleration; Concussive; Tauopathy; Repetitive

► Development of a new model of human repetitive mild TBI using mice as subjects. ► Method can be used repetitively to impart diffuse closed-head injury without causing skull fracture, intracranial bleeding or seizures. ► Neurological and behavioral effects are mild and show recovery over time. ► Hi...