Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials - Lin, Ann; Giuliano, Christopher J; Palladino, Ann; John, Kristen M; Abramowicz, Connor; Yuan, Monet Lou; Sausville, Erin L; Lukow, Devon A; Liu, Luwei; Chait, Alexander R; Galluzzo, Zachary C; Tucker, Clara; et al. (Science translational medicine, 2019)
Keywords: Antineoplastic Agents - toxicity; Cell Line, Tumor; Clinical Trials as Topic; Clone Cells; CRISPR-Cas Systems - genetics; Cyclin-Dependent Kinases - antagonists & inhibitors; Cyclin-Dependent Kinases - metabolism; Drug Resistance, Neoplasm - drug effects; Gene Knockout Techniques; Genome, Human; Humans; Molecular Targeted Therapy; Quinolones - pharmacology; RNA Interference - drug effects; Up-Regulation - drug effects