DNA Helicase–Polymerase Coupling in Bacteriophage DNA Replication

• Published in: Viruses Vol. 13; no. 9; p. 1739
• Main Authors: Lo, Chen-Yu, Gao, Yang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31.08.2021; MDPI
• Subjects: Archaea; bacteriophage T4; Bacteriophage T4 - genetics; bacteriophage T7; Bacteriophage T7 - genetics; bacteriophage Φ29; bacteriophages; Binding sites; Deoxyribonucleic acid; DNA; DNA biosynthesis; DNA helicase; DNA helicases; DNA Helicases - chemistry; DNA Helicases - genetics; DNA Helicases - metabolism; DNA replication; DNA Replication - physiology; DNA structure; DNA, Viral - chemistry; DNA-Binding Proteins - chemistry; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; DNA-directed DNA polymerase; DNA-Directed DNA Polymerase - chemistry; DNA-Directed DNA Polymerase - genetics; DNA-Directed DNA Polymerase - metabolism; energy; Enzymes; genome; Genomes; helicase; Kinetics; Models, Molecular; Molecular modelling; Phages; polymerase; Proteins; Replication; Review; RNA; RNA viruses; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Replication - physiology; DNA replication; helicase; bacteriophage T7; polymerase; bacteriophage T4; bacteriophage Φ29

Bacteriophages have long been model systems to study the molecular mechanisms of DNA replication. During DNA replication, a DNA helicase and a DNA polymerase cooperatively unwind the parental DNA. By surveying recent data from three bacteriophage replication systems, we summarized the mechanistic ba...