Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling

• Published in: Redox biology Vol. 47; p. 102139
• Main Authors: Liu, Shengnan, Pi, Jingbo, Zhang, Qiang
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.11.2021; Elsevier
• Subjects: KEAP1; NRF2; Oxidative stress; Protein sequestration; Research Paper; Ultrasensitivity; Zero-order degradation; Zero-order degradation; Ultrasensitivity; Oxidative stress; Protein sequestration; KEAP1; NRF2

Under oxidative and electrophilic stresses, cells launch an NRF2-mediated transcriptional antioxidant program. The activation of NRF2 depends on a redox sensor, KEAP1, which promotes the ubiquitination and degradation of NRF2. While a great deal has been learned about this duo, its quantitative sign...