EMT-Mediated Acquired EGFR-TKI Resistance in NSCLC: Mechanisms and Strategies

• Published in: Frontiers in oncology Vol. 9; p. 1044
• Main Authors: Zhu, Xuan, Chen, Lijie, Liu, Ling, Niu, Xing
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 11.10.2019
• Subjects: acquired resistance; epidermal growth factor receptor tyrosine kinase inhibitors; epithelial-mesenchymal transition; non-small-cell lung cancer; Oncology; therapeutic strategies

Acquired resistance inevitably limits the curative effects of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), which represent the classical paradigm of molecular-targeted therapies in non-small-cell lung cancer (NSCLC). How to break such a bottleneck becomes a pressing probl...