Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial

• Published in: The lancet oncology Vol. 23; no. 4; pp. 479 - 490
• Main Authors: Tang, Ling-Long, Huang, Cheng-Long, Zhang, Ning, Jiang, Wei, Wu, Yi-Shan, Huang, Shao Hui, Mao, Yan-Ping, Liu, Qing, Li, Ji-Bin, Liang, Shao-Qiang, Qin, Guan-Jie, Hu, Wei-Han, Sun, Ying, Xie, Fang-Yun, Chen, Lei, Zhou, Guan-Qun, Ma, Jun
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2022; Elsevier Limited
• Subjects: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Cancer; Chemoradiotherapy; Chemoradiotherapy - adverse effects; Chemoradiotherapy - methods; Chemotherapy; Cisplatin; Clinical trials; Dermatomyositis; Dysphagia; Epstein-Barr virus; Hematology; Hematology, Oncology, and Palliative Medicine; Humans; Hypothyroidism; Intravenous administration; Lymph nodes; Lymphatic system; Metastases; Metastasis; Middle Aged; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - drug therapy; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Neoplasms - pathology; Neck; Neoplasm Recurrence, Local - pathology; Neoplasm Staging; Patients; Quality of life; Radiation; Radiation therapy; Spinal cord; Survival; Throat cancer; Toxicity; Translation; Tumors; Young Adult; China

The aim of this trial was to address whether elective ipsilateral upper-neck irradiation (UNI) sparing the uninvolved lower neck provides similar regional relapse-free survival compared with standard whole-neck irradiation (WNI) in patients with nasopharyngeal carcinoma. This open-label, non-inferio...