Renal Purge of Hemolymphatic Lipids Prevents the Accumulation of ROS-Induced Inflammatory Oxidized Lipids and Protects Drosophila from Tissue Damage

• Published in: Immunity (Cambridge, Mass.) Vol. 52; no. 2; pp. 374 - 387.e6
• Main Authors: Li, Xiaoxue, Rommelaere, Samuel, Kondo, Shu, Lemaitre, Bruno
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 18.02.2020; Elsevier Limited
• Subjects: Adaptation; Adaptive Immunity; Animal tissues; Animals; Antioxidants; Apoptosis; Carrier Proteins - chemistry; Carrier Proteins - genetics; Carrier Proteins - metabolism; Damage; Diglycerides - metabolism; Drosophila; Drosophila melanogaster - genetics; Drosophila melanogaster - immunology; Drosophila melanogaster - metabolism; Drosophila Proteins - chemistry; Drosophila Proteins - deficiency; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Environmental stress; excretion; Feces; Feces - chemistry; Flies; Hemolymph; Hemolymph - metabolism; Homeostasis; immune adaptation; immunity; Infections; Inflammation; Insects; Kidneys; Lipid metabolism; Lipid Metabolism - immunology; Lipid peroxidation; Lipid Peroxidation - immunology; Lipid-binding protein; Lipids; Malpighian tubules; Malpighian Tubules - immunology; Malpighian Tubules - metabolism; Mammals; MAP Kinase Signaling System - immunology; Metabolism; Organs; Peptides; Peroxidation; Phenotypes; Physiology; Protein Conformation; Purging; Reactive oxygen species; Reactive Oxygen Species - immunology; Reactive Oxygen Species - metabolism; ROS; stress; Stress response; Stress, Physiological - immunology; Wound healing; stress; homeostasis; immune adaptation; excretion; Drosophila; ROS; immunity; lipid peroxidation; Malpighian tubules

Animals require complex metabolic and physiological adaptations to maintain the function of vital organs in response to environmental stresses and infection. Here, we found that infection or injury in Drosophila induced the excretion of hemolymphatic lipids by Malpighian tubules, the insect kidney....