Effects of diet-induced obesity on protein expression in insulin signaling pathways of skeletal muscle in male Wistar rats

• Published in: International journal of general medicine Vol. 5; no. default; pp. 573 - 582
• Main Authors: Fatani, Sameer, Abubakari, Abdul-Razak, Itua, Imose, Wong, Christopher, Thomas, Cecil, Naderali, Ebrahim K
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2012; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Animals; Development and progression; Diabetes; Diet; diet-induced obesity; fenofibrate; Genetic aspects; Glucose; Insulin; Insulin resistance; insulin signaling; intramuscular lipids; Kinases; muscle; Muscles; Musculoskeletal system; Obesity; Original Research; Physiological aspects; Prognosis; Proteins; Risk factors; Rodents; Type 2 diabetes; United Kingdom; intramuscular lipids; fenofibrate; insulin signaling; diet-induced obesity; muscle

The prevalence of diet-induced obesity is increasing globally, and posing significant health problems for millions of people worldwide. Diet-induced obesity is a major contributor to the global pandemic of type 2 diabetes mellitus. The reduced ability of muscle tissue to regulate glucose homeostasis...