Inhibition of metamorphosis in tadpoles of Xenopus laevis exposed to polybrominated diphenyl ethers (PBDEs)

• Published in: Chemosphere (Oxford) Vol. 64; no. 2; pp. 328 - 338
• Main Authors: Balch, Gordon C., Vélez-Espino, Luis A., Sweet, Colleen, Alaee, Mehran, Metcalfe, Chris D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 01.06.2006; Elsevier
• Subjects: Administration, Oral; Amphibia. Reptilia; Animal, plant and microbial ecology; Animals; Anura; Applied ecology; Biological and medical sciences; Body Burden; Brominated flame retardant; Ecotoxicology, biological effects of pollution; Flame Retardants - toxicity; Freshwater; Fundamental and applied biological sciences. Psychology; General aspects; Injections, Intraperitoneal; Larva - drug effects; Larva - metabolism; Metamorphosis; Metamorphosis, Biological - drug effects; Phenyl Ethers - toxicity; Polybrominated Biphenyls - toxicity; Tadpole; Thyroid hormones; Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution; Water Pollutants, Chemical - toxicity; Xenopus; Xenopus laevis; Xenopus; Tadpole; Thyroid hormones; Brominated flame retardant; Metamorphosis; Xenopus laevis; Amphibia; Flame retardant; Salientia; Vertebrata; Larva; Development; Thyroid hormone; Developmental stage; Bromine Organic compounds; Inhibition

Tadpoles of the African clawed frog, Xenopus laevis were exposed, beginning at stage 50, to a commercial pentabromodiphenyl ether mixture (DE-71) through the diet. Subsequent experiments were conducted using a single intraperitoneal injection at stage 58 with limited quantities of two purified bromi...