The retinoid X receptor agonist, 9-cis UAB30, inhibits cutaneous T-cell lymphoma proliferation through the SKP2-p27kip1 axis

• Published in: Journal of dermatological science Vol. 90; no. 3; pp. 343 - 356
• Main Authors: Chou, Chu-Fang, Hsieh, Yu-Hua, Grubbs, Clinton J., Atigadda, Venkatram R., Mobley, James A., Dummer, Reinhard, Muccio, Donald D., Eto, Isao, Elmets, Craig A., Garvey, W. Timothy, Chang, Pi-Ling
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2018
• Subjects: 9-cis UAB30; Adolescent; Aged, 80 and over; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Bexarotene; Cell Cycle - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Cutaneous T-cell lymphoma; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Down-Regulation; Drug Evaluation, Preclinical; Fatty Acids, Unsaturated - pharmacology; Fatty Acids, Unsaturated - therapeutic use; Humans; Inhibitory Concentration 50; Lymphoma, T-Cell, Cutaneous - drug therapy; Lymphoma, T-Cell, Cutaneous - pathology; Male; Middle Aged; Naphthalenes - pharmacology; Naphthalenes - therapeutic use; p27kip1; Proteasome Endopeptidase Complex - drug effects; Proteasome Endopeptidase Complex - metabolism; PSMA7; Retinoid X Receptors - agonists; Retinoid X Receptors - metabolism; S-Phase Kinase-Associated Proteins - metabolism; Signal Transduction - drug effects; SKP2; Tetrahydronaphthalenes - pharmacology; p27kip1; Bexarotene; SKP2; PSMA7; 9-cis UAB30; Cutaneous T-cell lymphoma

•9-cis UA30 (UAB30) induces apoptosis and suppresses proliferation in CTCL cells.•Inhibition of G1 cell-cycle checkpoint by UAB30 involves the SKP2-p27kip1 axis.•UAB30, a RXR-selective agonist, may also have RXR-independent function.•UAB30 can be as effective as bexarotene in treating CTCL.•This res...