Protection by BCG Vaccine Against Tuberculosis: A Systematic Review of Randomized Controlled Trials

• Published in: Clinical infectious diseases Vol. 58; no. 4; pp. 470 - 480
• Main Authors: Mangtani, Punam, Abubakar, Ibrahim, Ariti, Cono, Beynon, Rebecca, Pimpin, Laura, Fine, Paul E. M., Rodrigues, Laura C., Smith, Peter G., Lipman, Marc, Whiting, Penny F., Sterne, Jonathan A.
• Format: Journal Article
• Language: English
• Published: Oxford OXFORD UNIVERSITY PRESS 15.02.2014; Oxford University Press
• Subjects: ARTICLES AND COMMENTARIES; Bacillus Calmette Guerin vaccine; Bacteria; Bacterial diseases; BCG Vaccine - administration & dosage; BCG Vaccine - immunology; Biological and medical sciences; Clinical trials; Confidence interval; Estimation bias; Fungal infections; Human bacterial diseases; Humans; Infants; Infectious diseases; Medical sciences; Meningeal tuberculosis; Meta-analysis; Miliary tuberculosis; Pulmonary tuberculosis; Randomized Controlled Trials as Topic; Regression analysis; Systematic review; Treatment Outcome; Tuberculin; Tuberculosis; Tuberculosis and atypical mycobacterial infections; Tuberculosis vaccine; Tuberculosis, Meningeal - epidemiology; Tuberculosis, Meningeal - prevention & control; Tuberculosis, Miliary - epidemiology; Tuberculosis, Miliary - prevention & control; Tuberculosis, Pulmonary - epidemiology; Tuberculosis, Pulmonary - prevention & control; Vaccines; Infection; Prevention; Immunoprophylaxis; Tuberculosis; BCG; Bacteriosis; Vaccine; Mycobacterial infection; Protection; Bibliographic review; meta-analysis; trials; vaccine efficacy; BCG vaccine; meta-regression

Background. Randomized trials assessing BCG vaccine protection against tuberculosis have widely varying results, for reasons that are not well understood. Methods. We examined associations of trial setting and design with BCG efficacy against pulmonary and miliary or meningeal tuberculosis by conduc...