Midazolam and propofol used alone or sequentially for long-term sedation in critically ill, mechanically ventilated patients: a prospective, randomized study

• Published in: Critical care (London, England) Vol. 18; no. 3; p. R122
• Main Authors: Zhou, Yongfang, Jin, Xiaodong, Kang, Yan, Liang, Guopeng, Liu, Tingting, Deng, Ni
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16.06.2014; BioMed Central
• Subjects: Akathisia, Drug-Induced; Analysis; Anesthesia Recovery Period; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - adverse effects; Anesthetics, Intravenous - economics; Cost benefit analysis; Critical Illness; Drug Administration Schedule; Drug Costs; Health aspects; Hospital Costs; Humans; Hypotension - chemically induced; Intensive Care Units - economics; Intention to Treat Analysis; Midazolam - administration & dosage; Midazolam - adverse effects; Midazolam - economics; Propofol - administration & dosage; Propofol - adverse effects; Propofol - economics; Prospective Studies; Respiration, Artificial; Treatment Outcome; Ventilator Weaning

Midazolam and propofol used alone for long-term sedation are associated with adverse effects. Sequential use may reduce the adverse effects, and lead to faster recovery, earlier extubation and lower costs. This study evaluates the effects, safety, and cost of midazolam, propofol, and their sequentia...