Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients

• Published in: Aging clinical and experimental research Vol. 32; no. 10; pp. 2141 - 2158
• Main Authors: Daneshkhah, Ali, Agrawal, Vasundhara, Eshein, Adam, Subramanian, Hariharan, Roy, Hemant Kumar, Backman, Vadim
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.10.2020; Springer Nature B.V
• Subjects: Aged; Betacoronavirus - immunology; Betacoronavirus - pathogenicity; C-reactive protein; C-Reactive Protein - analysis; Coronavirus Infections - epidemiology; Coronavirus Infections - immunology; Coronavirus Infections - mortality; Coronaviruses; COVID-19; Cytokine storm; Cytokines; Cytokines - immunology; Female; Geriatrics/Gerontology; Humans; Inflammation; Inflammation - immunology; Male; Medicine; Medicine & Public Health; Middle Aged; Mortality; Original; Original Article; Pandemics; Pneumonia, Viral - epidemiology; Pneumonia, Viral - immunology; Pneumonia, Viral - mortality; SARS-CoV-2; Vitamin D - immunology; Vitamin D - therapeutic use; COVID-19; SARS-CoV-2; Case mortality ratio; C-reactive protein; Vitamin D; Cytokine storm

Objectives We present evidence for a possible role of Vitamin D (VitD) deficiency in unregulated cytokine production and inflammation leading to complications in COVID-19 patients. Design The time-adjusted case mortality ratio (T-CMR) was estimated as the ratio of deceased patients on day N to the c...